cdc25b phosphatase

CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation.

M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM) and also exhibits anti-tumor activity. Additionally, M2N12 shows promising activity against Cdc25A (IC50 = 0.53 μM) and Cdc25B (IC50 = 1.39 μM).

CDC25-IN-2 (Compound 1d) is a selective inhibitor of the phosphatase Cdc25, exhibiting IC50 values of 44.4, 55.2, and 53.9 μM for human Cdc25A, Cdc25B, and Cdc25C respectively. By inhibiting Cdc25 phosphatase activity, CDC25-IN-2 can halt cell cycle progression and is applicable for cancer research.

JMS-053 is a potent and selective inhibitor of the phosphatase DUSP3, inhibits PTP4A3, PTP4A1, PTP4A2 and CDC25B, inhibits cancer cell migration and sphere growth, and avoids disruption of the microvascular endothelial barrier by vascular endothelial growth factor or lipopolysaccharide.

NSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively).

Cryptosporioptide A (Compound 3), a protein tyrosine phosphatase inhibitor, originates from the insect-parasitic fungus Cordyceps gracilioides. This compound effectively inhibits several enzymes including PTP1B, SHP2, CDC25B, LAR, and SHP1 with respective IC50 values of 7.3, 5.7, 7.6, >50, and 4.9 μg/mL [1].

BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.