cd47

Expression system: HEK293 Cells
Length: 19-139, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-139, Partial
Activity: BLI

Expression system: HEK293 Cells
Length: 19-139, Partial
Activity: BLI

Expression system: HEK293 Cells
Length: 19-139, Partial
Activity: BLI

CD47 Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is F7A802.

CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain, five membrane-spanning regions with short intervening loops, and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA, it binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cellcell adhesion, it enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. It may play a role in membrane transport and or integrin dependent signal transduction. It also prevents premature elimination of red blood cells.

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers.

Expression system: HEK293 Cells
Length: 19-140, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-140, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-139, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-139, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-140, Partial
Activity: ELISA、SPR

Expression system: HEK293 Cells
Length: 1-139, Partial
Activity: ELISA、SPR、BLI

Expression system: HEK293 Cells
Length: 1-140, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-139, Partial
Activity: Not Tested

CD47 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is A0A2K5X4H8.

CD47 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is XP_005548291.1&NP_001253446.1.

Expression system: HEK293 Cells
Length: 1-140, Partial
Activity: Not Tested

CD47 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.8 kDa and the accession number is E5Q371.

Expression system: HEK293 Cells
Length: 1-140, Partial
Activity: ELISA

CD47 Protein, Human, Recombinant (aa 19-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.17kDa and the accession number is NP_942088.1.

Expression system: HEK293 Cells
Length: 29-360, Extracellular Domain
Activity: Not Tested

Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation

Expression system: HEK293 Cells
Length: 31-370, Extracellular Domain
Activity: BLI