cap 18

CAP18 (rabbit) is a 37-amino-acid antimicrobial peptide derived from rabbit granulocytes, exhibiting extensive antimicrobial activity against both Gram-positive [IC50, 130-200 nM] and Gram-negative bacteria [IC50, 20-100 nM]. CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.

LL-37 (18-37), an antimicrobial peptide fragment of LL-37, exhibits activity against S. aureus and C. albicans, with minimum lethal concentrations of 4 µM and 10 µM, respectively. Additionally, it inhibits E. histolytica trophozoites growth at concentrations between 10 to 50 µM.

2',3'-O-Isopropylideneguanosine is an alkylated guanosine building block.1,2It has been used in the synthesis of ordered honeycomb microporous films and mRNA cap analogs. 1.Gao, Y.-F., Huang, Y.-J., Xu, S.-Y., et al.Ordered honeycomb microporous films from self-assembly of alkylated guanosine derivativesLangmuir27(6)2958-2964(2011) 2.Kore, A.R., Shanmugasundaram, M., and Vlassov, A.V.Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analogBioorg. Med. Chem. Lett.18(17)4828-4832(2008)

7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].