c-132

Bovine Myeloid Antimicrobial Peptide (BMAP) 28, a synthetic peptide derived from bovine cathelicidin-5 (amino acids 132-158), exhibits antimicrobial activity against E. coli, S. aureus, MRSA, S. epidermidis, and the fungus C. albicans, with minimum inhibitory concentrations (MICs) of 2, 2, 4, 1, and 8 µM respectively. At a concentration of 200 nM, BMAP 28 permeabilizes the inner membrane of E. coli, and at 5 µM, it inhibits herpes simplex virus 1 (HSV-1) replication in Vero 76 cells. Furthermore, at 30 µM, it causes hemolysis in human erythrocytes and cytotoxicity in human neutrophils. In vivo, a dose of 0.8 mg/kg enhances survival in mice infected with E. coli or MRSA, but not P. aeruginosa.

BMAP 28, bovine, is an antimicrobial peptide. It demonstrates antibacterial activity against both Gram-positive and Gram-negative bacteria by increasing cell membrane permeability and causing leakage of cell contents. Furthermore, BMAP 28, bovine, exhibits cytotoxic effects on cancer cells and activated human lymphocytes. It induces apoptosis through mitochondrial membrane potential depolarization.