bcl6 in 6

BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.

BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines, making it valuable for tumor-related research [1].

BCL6ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). It can be utilized in synthesis.

BCL6ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). It serves as an active control for the target protein ligand BMS-986458.

BCL6ligand-4 is a BCL6 ligand used in the synthesis of PROTACs, such as BCL6PROTAC 1.

PROTACBCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader with an IC50 of 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells. It facilitates the ubiquitination and degradation of BCL6, exhibiting anticancer activity against BCL6-dependent diffuse large B-cell lymphoma. [Pink: BCL6 ligand; Blue: E3 ligase ligand; E3 ligase ligand + linker.]

BCL6-IN-7 (BCL6 inhibitor-7) is a BCL6 co-repressor interaction inhibitor with potential anticancer activity. It can be used for studying lymphomas.

BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.

BCL6-IN-8c is an orally active and potent inhibitor of B-cell lymphoma 6 (BCL6)-corepressor interaction(IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay).

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. It selectively degrades BCL6 without affecting other CRBN substrates. Significant efficacy was demonstrated by BCL6-760 in an OCI-LY-1 tumor xenograft mouse model. This compound is applicable in diffuse large B-cell lymphoma (DLBCL) research.

BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].

CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove.

Thalidomide-piperazine-Boc, an intermediate used in the synthesis of BCL6 PROTAC, targets the B-cell lymphoma 6 protein.

BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.

BCL6-IN-9 (compound 1) is a potent inhibitor of B-cell lymphoma 6 protein (BCL6) with an IC50 of 3.9 nM and is utilized for cancer research.

OICR12694 (JNJ-65234637) TFA, an orally active B cell lymphoma 6 (BCL6) inhibitor [1], demonstrates effectiveness in targeting BCL6 pathways.