aristolochic

Aristolochic acid A is the main component of the plant extract aristolochic acids, primarily found in the herbaceous plants Aristolochia and Asarum. It significantly inhibits the activity of activator protein 1 (AP-1) and NF-κB, and downregulates the expression of the bladder cancer-associated BLCAP gene in human cells. It is commonly used to induce nephrotoxicity models.

Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.

Aristolochic acid Va, a natural compound, is isolated from Aristolochia plants [1].

Aristolochic acid III, a naturally occurring compound, is extracted from Aristolochia debilis leaves [1].

Aristolochic acid C, a derivative of Aristolochic acid, acts as a phospholipase A2 inhibitor.

Aristolochic Acid D, a derivative of aristolochic acid isolated from the stems of Aristolochia indica, is identified as both a carcinogen and nephrotoxin.

Sodium aristolate 1, also known as aristolochic acid sodium salt, is found in certain Chinese herbal medicines and causes nephrotoxicity. This proagent becomes active when its nitro groups are reduced to amines, which subsequently leads to the production of cytotoxic DNA adducts.

Aristolochic acid BLL methyl ester is a natural product that can be used in related research in the field of life sciences. Its product number is TN8523.

Aristolochic acid Ia is the oxidized metabolite of Aristolochic acid I and serves as a tool for studying the detoxification pathways of Aristolochic acid metabolism.

7-Hydroxyaristolochic acid A is a natural derivative of aristolochic acid. Aristolochic acid is nephrotoxic and carcinogenic, inhibits APE1 Nrf2 HO-1 axis-induced oxidative stress and apoptosis leading to nephrotoxicity, and induces apoptosis in NRK-52E cells via COX-2 and PGE2.

12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1].