antithrombin-heparin

H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, it is employed for quantifying antithrombin-heparin cofactor (AT-III) and is characterized by its sensitivity, accuracy, and ease of implementation.

Naroparcil, an orally available thioglycoside analog of 4-methylumbelliferyl β-D-xyloside, showed antithrombotic effects in the Wessler sludge model of venous thrombosis (jugular vein).Naroparcil enhanced the formation of the thrombin/heparin cofactor II complex, induced dermatophyte sulfate-like substances in plasma from treated rabbits appearance, but reduced the formation of thrombin/antithrombin III complexes in plasma incubated with (125I)-human alpha-thrombin.

Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse proteins for numerous important biological activities.Heparin sodium salt (Sodium heparinate) significantly inhibits exosome-cell interactions.

Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events.

Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percutaneous coronary intervention (PCI)

H-D-Phe-Pip-Arg-pNA acetate is a chromogenic substrate whose sequence mimics the N-terminal region of thrombin's natural substrate fibrinogen α-chain. It is highly specific to thrombin and can be used for the activity detection of antithrombin Ⅲ heparin cofactor (AT-III). The AT-III detection method based on this chromogenic substrate features high sensitivity, accurate results and simple operation.

H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, mimics the N-terminal segment of the A alpha chain of fibrinogen, the native substrate of thrombin. It is specific to thrombin and is used for quantifying antithrombin-heparin cofactor (AT-III), enabling a sensitive, accurate, and straightforward AT-III assay.

Fondaparinux sodium (Arixtra, SR-90107A) is a synthetic heparin anticoagulant and an antithrombin-dependent factor Xa inhibitor (IC50=1909 nM), with high selectivity, low immunogenicity, and favorable pharmacokinetic properties, used for the prevention and treatment of thrombotic diseases.

Heparin Lithium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII) and enhances its inhibitory effect on coagulation factors, such as thrombin and factor Xa, significantly enhancing anticoagulant activity.

Heparin (Nadroparin) calcium (MW 3600-5000), an anticoagulant, forms a reversible complex with antithrombin III (ATIII), known as the heparin-antithrombin III complex. This complex then irreversibly binds to and inactivates thrombin and other activated clotting factors IX, X, XI, and XII, thereby inhibiting the conversion of fibrinogen to fibrin [1] [2].

Heparin calcium (MW 15000-19000), an anticoagulant, forms a reversible complex with antithrombin III (ATIII), known as the heparin-antithrombin III complex. This complex binds to thrombin and the activated clotting factors IX, X, XI, and XII, leading to their irreversible inactivation and inhibiting the conversion of fibrinogen into fibrin [1] [2].

Protamine from salmon is a biochemical reagent with antioxidant, anti-heparin, and antimicrobial properties. It can neutralize the anticoagulant effect of heparin, preventing the formation of antithrombin complexes in canine samples pretreated with heparin in vitro.