anti-protozoal

Diloxanide (RD3803) is an endomoeba insecticide. It is considered to be the luminal agent of choice for patients with mild enteroamoebiasis or asymptomatic cysts.

Toltrazuril sulfone (Ponazuril) is an antiprotozoal agent that acts upon Coccidia parasites.

Nifursemizone (Etafurazone) is an agent with antiprotozoal.

Carnidazole (ME-108) shows antiprotozoal activity and can be used in studies about the treatment of Trichomonas infection.

Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.

Broxaldine (Brobenzoxaldine) is a small molecular drug with antiprotozoal activity.

Benznidazol (Benznidazole)e has an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.

Metronidazole (acetic acid) is a metabolite derived from Metronidazole, exhibiting mutagenic activity in bacteria. As a nitroimidazole antibiotic, amebicide, and antiprotozoal agent, Metronidazole is specifically utilized against protozoa and anaerobic bacteria.

DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.

Quinacrine dihydrochloride hydrate possesses antiprotozoal and anti-infective properties and exhibits multi-target biological activity; it inhibits voltage-gated sodium channels (which are involved in the generation and conduction of action potentials) and aldehyde oxidase activity, and acts as a riboflavin antagonist to interfere with riboflavin-related protein interactions; Furthermore, quinacrine has been used in in vitro models to study the regulation of prion misfolding processes.

Quinacrine analog 34 is a potent autophagy inhibitor (EC₅₀ = 0.5 μM, LD₅₀ = 27 μM) that upregulates the protein levels of the autophagy marker LC3-II and induces lysosomal deacidification.

Teclozan is an antiprotozoal agent of the benzylamine derivative class. teclozan exhibits anti-G. intestinalis effects in the intestinal lumen, interferes with phospholipid metabolism and prevents the formation of arachidonic acid. teclozan can be used to study protozoal infections.

Pinafide is a rodenticide and anti-protozoal agent. Pinafide shows strong cytostatic activity against both HeLa and KB cells and is moderately toxic to both mice and rats. It has been proved active against experimental tumors and shown to be inhibitor of two DNA viruses. Pinafide blocks cell growth by inhibiting DNA and RNA synthesis. It has been shown to bind to double-helical DNA by intercalation. Pinafide inhibited the activity of M. tuberculosis NAD⁺-dependent DNA ligase A at concentrations of 50 uM. At the chemical screening was found that pinafide inhibited B-Myb transcriptional activity in luciferase assays. The cross placental-barrier studies showed that 3H-pinafide was present in the 14-day fetuses.

Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-protozoal activity with a minimum inhibitory concentration (MIC) of 2 to 20 μg/mL [1].

Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.