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Results for "

anti-diabetes

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    58
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    1
    TargetMol | Compound_Libraries
  • Natural Products
    26
    TargetMol | Natural_Products
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    4
    TargetMol | Recombinant_Protein
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    TargetMol | Isotope_Products
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    TargetMol | Disease_Modeling_Products
Acarbose
BAY g 5421
T024756180-94-0
Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.
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DGAT-1 inhibitor 2
T11016942999-61-3In house
DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor and anti-obesity drug. DGAT-1 (acyl-CoA: diacylglycerol acyltransferase 1) is one of two known DGAT enzymes that catalyze the final step of triglyceride synthesis. Transgenic mice and pharmacological studies indicate that inhibiting DGAT1 is a promising strategy for treating obesity and type 2 diabetes.
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8-10 weeks
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TargetMol | Inhibitor Sale
(R)-Lisofylline
(R)-Lisophylline
T21694100324-81-0In house
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM) that interrupts IL-12 signaling-mediated STAT4 activation, making it useful for studies on the treatment of type 1 diabetes and autoimmune disorders.
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Cerebrocrast
IOS-11212, IOS11212, IOS 11212
T26982118790-71-9In house
Cerebrocrast (IOS-11212) is an anti-inflammatory and hypoglycemic activity that promotes H+ and Cl- cotransport in rat liver mitochondria, blocks human platelet activation, and can be used to study diabetes.
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6-8 weeks
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(±)4-HDHA
4-Hydroxy docosahexaenoic acid, (±)4-HDoHE
T3660290906-40-4In house
(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is a PPARγ agonist with anti-inflammatory activity that directly inhibits endothelial cell proliferation and sprouting angiogenesis via PPARγ, which can be used in the study of diabetes.
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Enpp-1-IN-16
T781692289739-47-3In house
Enpp-1-IN-16 is an inhibitor targeting ENPP1 with potential anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance in relation to type II diabetes mellitus and various ENPP1-mediated diseases in the chondrocalcinosis and osteoarthritis classes.
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8-10 weeks
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(S)-OSMI 3
Ent-OSMI-3
T836462411972-78-4In house
(S)-OSMI 3 (Ent-OSMI-3) has anti-inflammatory and anti-tumour activity and can be used to study diabetes and neurodegenerative diseases.
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Sitagliptin
MK0431
T0242486460-32-6
Sitagliptin (MK0431), a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either alone or in combination with metformin or thiazolidinedione for treatment of type 2 diabetes mellitus. The drug can competitively inhibit a protein enzyme and DPP-4, that leads to an incremental amount of active incretins (GLP-1 and GIP), the diminished amount of release of glucagon and increased release of insulin.
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Hexylresorcinol
4-Hexylresorcinol
T0314136-77-6
Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene utilized topically as an antiseptic for minor skin infection treatment.
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Metformin hydrochloride
Metformin HCl, 1,1-Dimethylbiguanide hydrochloride, 1, 1-Dimethylbiguanide hydrochloride
T07401115-70-4
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride), a widely used anti-diabetic drug, exhibits potential anti-Y properties by inhibiting the proliferation of various Y cells, including colon and prostate.
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Genipin
(+)-Genipin
T22106902-77-8
Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.
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Acetyl-L-carnitine hydrochloride
O-Acetyl-L-carnitine hydrochloride, O-acetyl-L-carnitine hcl, O-Acetylcarnitine hcl, Acetyl L-carnitine hydrochloride
T25635080-50-2
Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) is a nutritional supplement composed of the hydrochloride salt form of the acetylated form of the endogenously produced L-carnitine, with potential neuroprotective, cognitive-enhancing, anti-depressive and immunomodulating activities. It may also relieve peripheral neuropathy induced by chemotherapy, diabetes or other diseases. In addition, acetyl-L-carnitine may modulate the immune response by increasing T-lymphocytes maturation and may downregulate pro-inflammatory cytokines in response to viruses, such as SARS-CoV-2. It may also disrupt the ACE2 signaling pathway and inhibit the production of reactive oxygen species (ROS).
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Glabridin
Q-100692, LS-176045, KB-289522
T340359870-68-7
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
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1-Deoxynojirimycin
Moranoline, moranolin, Duvoglustat
T367519130-96-2
1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
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L-Arginine
L-Arg, (S)-(+)-Arginine
T3S036474-79-3
1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate lymphocyte proliferation through an interleukin-2-independent pathway. 4. A combination of oral L-citrulline and L-Arginine effectively and rapidly augments NO-dependent responses at the acute stage.
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Vicenin 2
Vicenin -2
T385123666-13-9
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants.
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kuwanon G
Moracenin B, Kuwanone G
T3S161275629-19-5
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
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lobeglitazone sulfate
Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang, CKD-501 Sulfate, CKD501 Sulfate, CKD-501, CKD501, CKD 501 Sulfate, CKD 501
T27841763108-62-9
Lobeglitazone Sulfate(CKD-501 Sulfate) is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2 diabetes mellitus (T2DM).
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6-8 weeks
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NSC 6038
4-chloro-N,N-dipropylbenzamide, 4-Chloro-N,N-di-n-propylbenzaMide
T46322447-87-2
NSC-6038 (4-chloro-N,N-dipropylbenzamide) is a benzamide-based bioactive compound with a wide range of biological activities and has been shown to possess anti-inflammatory, antioxidant and anti-angiogenic activities, and has also been shown to be effective in the treatment of a wide range of diseases such as cancer, diabetes and cardiovascular diseases.
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Mitiglinide Calcium
KAD-1229, S21403
T6587145525-41-3
Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
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Procyanidin A2
TN113241743-41-3
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activities. Procyanidin A2 demonstrates liver cell regenerative activity in scratch w
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beta-Glucogallin
1-O-Galloyl-β-D-glucose, β-Glucogallin
T12602213405-60-2
beta-Glucogallin (beta-Glucogallin) is a selective aldose reductase (AKR1B1) inhibitor with antioxidant, anti-glycation, and anti-inflammatory properties. beta-Glucogallin is a naturally occurring compound derived from Emblica officinalis and is used in diabetes research. Vitamin B3-d4
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SB-657510
T12848474960-44-6
SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.
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6-8 weeks
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Masticadienonic acid
Masticadienoic acid
T131480514-49-8
Masticadienonic acid is a compound derived from Chios mastic gum, with potential anti-inflammatory and anti-cancer activities. It alleviates colitis in mice by modulating inflammatory responses, gut barrier integrity, and the microbiome. Masticadienonic acid is a potential protein tyrosine phosphatase 1B (PTP1B) inhibitor and can be used for research on diabetes.
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