anti-atherogenic

Oleuropein is an antioxidant polyphenol isolated from olive leaf.

3',4'-Dimethoxyflavone is a standard flavonoid compound with numerous medicinal activities.

Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Taurine is involved in a number of processes related to energy expenditure and muscle function, and can treat fatigue and muscles as well as improve immune function.

Gypenoside XIII is a Gynostemma pentaphyllum-derived gypenoside that exhibits pharmacological actions consistent with its structural class, including anti-Alzheimer’s disease, anticancer, and anti-atherogenic activities, supporting its emerging significance as a multifunctional natural compound with broad therapeutic potential for neurodegenerative and systemic disorders.

Pitavastatin (NK-104) sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and an inducer of the hepatocyte low-density lipoprotein cholesterol (LDL-C) receptor. It inhibits acetate synthesis of cholesterol in HepG2 cells and exhibits anti-atherogenic, anti-osteoarthritic, anti-asthmatic, anti-tumour, neuroprotective, hepatoprotective, and nephroprotective effects.

Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor that targets ACAT1 with an IC50 value of 4.9 μM and ACAT2 with an IC50 value of 3.0 μM. Pactimibe sulfate (CS-505) inhibits oleoyl-CoA noncompetitively with a Ki value of 5.6 μM and significantly suppresses cholesterol ester formation with an IC50 value of 6.7 μM. Pactimibe sulfate (CS-505) reduces plasma cholesterol activity and demonstrates anti-atherogenic potential. Pactimibe sulfate (CS-505) is applicable to lipid metabolism, atherosclerosis, and cholesterol homeostasis-related research.

G* peptide, also known as LVGRQLEEFL (mouse) TFA, is a segment corresponding to amino acids 113 to 122 ([113,122] apoJ) of apolipoprotein J. This compound possesses both anti-inflammatory and anti-atherogenic qualities. When combined with an apoJ mimetic, it constitutes the HM-10/10 peptide, a novel chimeric high-density lipoprotein mimetic peptide. The HM-10/10 peptide is notable for safeguarding retinal pigment epithelium (RPE) and photoreceptors from oxidant-induced cell death as referenced in sources [1] [2].

G* Peptide, also denoted as LVGRQLEEFL (mouse), represents the amino acid sequence 113 to 122 ([113,122] apoJ) found in apolipoprotein J. This compound displays both anti-inflammatory and anti-atherogenic characteristics. When incorporated into an apoJ mimetic, it results in the formation of the HM-10/10 peptide, which functions as a novel chimeric high-density lipoprotein. The HM-10/10 peptide has been shown to confer protection to the retinal pigment epithelium (RPE) and photoreceptors against oxidant-induced cell death [1] [2].

Miquelianin (Standard) is a reference standard for research and analysis in studies involving Miquelianin. Miquelianin (Quercetin 3-glucuronide) is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities.

Gypenoside XIII (Standard) is a reference standard for research and analysis in studies involving Gypenoside XIII. Gypenoside XIII is a Gynostemma pentaphyllum-derived gypenoside that exhibits pharmacological actions consistent with its structural class, including anti-Alzheimer’s disease, anticancer, and anti-atherogenic activities, supporting its emerging significance as a multifunctional natural compound with broad therapeutic potential for neurodegenerative and systemic disorders.

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

Momordicosides K and L, the main bitter taste triterpene glycosides in Bitter melon; and bitter melon has been reported to have hypoglycemic, anti atherogenic and anti HIV activities.

Pyrogallol-phloroglucinol-6,6-bieckol (PPB) is a bioactive phlorotannin compound isolated from the brown alga Ecklonia cava that exerts potent anti-inflammatory and anti-atherogenic activities by inhibiting monocyte migration and macrophage differentiation toward inflammatory phenotypes. Pyrogallol-phloroglucinol-6,6-bieckol reduces monocyte-induced endothelial cell death and suppresses vascular smooth muscle cell proliferation and migration, contributing to vascular protection and potential therapeutic modulation of inflammatory vascular diseases.

KRES peptide, an apolipoprotein with four amino acid residues, interacts with lipids, reduces lipoprotein lipid hydroperoxides (LOOH), activates antioxidant enzymes associated with high-density lipoprotein, and exhibits anti-inflammatory and anti-atherogenic properties. KRES peptide is also orally active [1].

Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

Miquelianin (Quercetin 3-glucuronide) is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities.