akr1c1

AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).

Liquiritin (Liquiritigenin-4'-O-glucoside) (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.

S07-2010 is an AKR1C3 inhibitor with potential anti-cancer activity, suppressing AKR1C3, AKR1C4, AKR1C1, and AKR1C2, inducing apoptosis in A549/DDP cells. S07-2010 exhibits significant cytotoxicity in MCF-7/DOX and A549/DDP.

1-Tetralol, (S)- ((S)-1-Hydroxytetralin) can be used as a substrate of AKR1C1 in cell assays.

AKR1Cs-IN-1 (Compound 29) is an effective and broad-spectrum inhibitor of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). It achieves subtype inhibition by simultaneously binding to the SP2 and SP3 pockets, thereby blocking metabolic pathways related to drug resistance. In enzyme assays, AKR1Cs-IN-1 exhibits significant inhibitory activity with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. The compound shows excellent resensitizing effects in doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, effectively enhancing the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on breast cancer resistance.

Keap1-Nrf2-IN-28 (SG16) is an orally active inhibitor of Keap1-Nrf2. It demonstrates antioxidant properties and upregulates the expression of Nrf2, HO-1, GCLM, and Akr1c1. Additionally, Keap1-Nrf2-IN-28 can mitigate acute liver injury induced by APAP.

PROTACAKR1C3 degrader-1 (compound 5) is an efficient AKR1C3 PROTAC degrader. It effectively reduces the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTACAKR1C3 degrader-1 shows potential for research in prostate cancer.

SG-55 is a selective, non-competitive, orally active inhibitor of AKR1C3, with an IC50 of 5 nM and a Ki of 10 nM. It has over 2000-fold higher selectivity for AKR1C3 compared to AKR1C1, AKR1C2, and AKR1C4 (>10 μM). SG-55 enhances the NADPH/NADP+ ratio, decreases the GSH/GSSG ratio, and induces DNA double-strand breaks. Additionally, SG-55 can overcome resistance to Osimertinib mediated by the EGFRC797S triple mutation in non-small cell lung cancer (NSCLC).

AKR1C1 inhibitor

CPSA is an effective and selective AKR1C1 inhibitor.

Liquiritin (Standard) is a reference standard for research and analysis in studies involving Liquiritin. Liquiritin (Liquiritigenin-4'-O-glucoside) (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.