abacavir

Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.

Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity

Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection.

Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].

ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir 5′-phosphate serves as a substrate for adenosine deaminase-like protein 1 (ADAL1). It is potentially useful for research related to HIV infection.

(R,R)-Abacavir is the (R,R)-enantiomer of Abacavir. Abacavir is an orally active, competitive nucleoside reverse transcriptase inhibitor. It inhibits HIV replication and demonstrates anticancer activity in prostate cancer cell lines. Additionally, Abacavir can cross the blood-brain barrier and suppress telomerase activity.

Abacavir impurity 5 (trans-Abacavir Hydrochloride) is an impurity of Abacavir.

Abacavir impurity 3 is an impurity of Abacavir.

Abacavir impurity 6 is an impurity of Abacavir.

Abacavir impurity 2 is a contaminant found in Abacavir.

Abacavir impurity 4 is an impurity of Abacavir.

Abacavir impurity 9 is a constituent that exists as an impurity within Abacavir.

Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.

Abacavir-D4 is a deuterated compound of Abacavir. Abacavir (T1267) has a CAS number of 136470-78-5. Abacavir (T1267) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.

Abacavir-[D5] (Standard) is a reference standard of Abacavir-[D5] intended for quantitative analysis, quality control, and related biochemical research applications.

9-((1R,4S)-4-(tert-Butoxymethyl)cyclopent-2-en-1-yl)-N6-cyclopropyl-9H-purine-2,6-diamine is a useful organic compound for research related to life sciences and the catalog number is T64644.

Scopadulciol is and enzyme and proton pump inhibitor.

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.

2-Amino-6-cyclopropylamino-9H-purine,the key intermediate of abacavir was synthesized from ethyl cyanoacetate by nitrosation,cyclization with guanidine hydrochloride in the presence of EtONa and reduction to give 2,4,5-triamino-6-hydroxypyrimidine

(+)-Carbovir triphosphate, an active metabolite of Abacavir, was utilized to study the molecular mechanism of inhibition and drug resistance in HIV-1 reverse transcriptase.