T2015

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.

Naxagolide is a sustained release formulation. It is a dopamine agonist.

Geranyl butyrate (NSC 46146) is a flavor commonly used in the food and cosmetic industries.

Brimonidine (Bromoxidine) is a drug used as eye drops under the brand names Alphagan and Alphagan-P. It is used to treat open-angle glaucoma or ocular hypertension

KSQ-4279 (gentisate) (Compound Formula I) serves as an effective inhibitor of USP1 and a selective inhibitor of PARP1. This compound shows promise for use in cancer research.

Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).

PROTAC BRM/BRG1 degrader-2 (Example.004) is a potent PROTAC BRM/BRG1 degrading agent exhibiting a DC50 of less than 10 nM and an IC50 of 15 nM in A549 cells.

3-Hydroxy-3'-nitro-2-naphthanilide (IC₅₀ = 12 μM) is an inhibitor of human cytomegalovirus DNA polymerase α. 3-Hydroxy-3'-nitro-2-naphthanilide can be used in infection-related research.

E3 Ligase Ligand 43 is an E3 ubiquitin ligase ligand for ACBI3, used in the synthesis of PROTACs.

LD03-DEX is a precursor compound of dexamethasone, characterized by its immunosuppressive activity.

Tetraconazole is an agent of pesticides.

FFAR1/FFAR4 agonist-1 (compound 83) is an agonist targeting both FFAR1 and FFAR4, with EC50 values of 1 nM and 4 nM respectively. This compound is used in research for glycemic control.

6-Aminocaproic acid-(S,R,S)-AHPC-Me serves as a ligand and linker for the E3 ubiquitin ligase in PROTACs, facilitating the synthesis of PVD-06 for research in oncology.

Amino-PEG4-(S,R,S)-AHPC-Me is a ligand+linker conjugate for E3 ubiquitin ligases. It is utilized in the synthesis of PROTACNR-V04.

Pan-KRAS Ligand 1 serves as a ligand for the target protein of PROTAC (Ligand for Target Protein for PROTAC). This compound facilitates the synthesis of PROTAC Pan-KRAS Degrader 4.

Antibacterialagent 252 hydrochloride, an amino acid derivative, exhibits antibacterial activity. It enhances the efficacy of Colistin sulfate in killing a broad spectrum of Gram-negative bacteria by targeting bacterial membranes.

Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.

CQ-16 is an orally active small molecule drug conjugate (SMDC) that targets prostate-specific membrane antigen (PSMA). It exhibits high selectivity in its antiproliferative activity between PSMA-positive and PSMA-negative prostate cells. Additionally, CQ-16 possesses PARP inhibitory activity (IC50=1 nM).

PROTAC SMARCA2 degrader-29 (Example 87) is a potent PROTAC SMARCA2 (BRM) degrading agent with a DC50 ranging between 10-100 nM (BRM) and over 1 μM (BRG1, also known as SMARCA2).

SORT1-IN-1 (compound 2) is a SORT1 inhibitor.

Ceftolozane TFA is a cephalosporin class antibiotic (antibiotic) designed to inhibit Gram-negative bacterial infections. Additionally, it can be utilized in the synthesis of novel antibiotics (antibiotic) that are more efficacious and safer.

Lansoprazole sulfone is a metabolite of the gastric pump inhibitor Lansoprazole.

Nrf2 activator 17 (compound 10) is an Nrf2 agonist that inhibits the interaction between Keap1 and Nrf2 with an IC50 value of <0.1 pM. In HepG2 cells, it demonstrates an EC50 of <10 μM.

(S)-Norfluoxetine, the S enantiomer of Norfluoxetine, functions as a selective serotonin reuptake inhibitor. It enhances allopregnanolone levels and reduces aggression in socially isolated mice.