T1032

Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.

T-1032 is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. It induces relaxation in isolated rabbit corpus cavernosum and is applicable in the study of erectile dysfunction.

Androgen receptor antagonist 1 is an orally available full antagonist of the androgen receptor (AR), with an IC50 value of 59 nM, demonstrating high potency against AR signaling. Androgen receptor antagonist 1 can further be employed in the synthesis of PROTAC AR degraders, which induce targeted protein degradation, achieving 24% and 47% AR protein reduction in LNCaP cells at concentrations of 1 μM and 10 μM, respectively, thereby offering significant utility in prostate cancer research.

Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor (Ki: 0.18 μM) that inhibits estrogen biosynthesis, exhibits antifertility effects, and induces impairment of spatial memory.

ANI-7 is an activator of the aryl hydrocarbon receptor (AhR) pathway, inhibiting the growth of various cancer cells and selectively inhibiting the growth of MCF-7 breast cancer cells (GI50: 0.56 μM).

Anti-TB agent 1 is a potent and orally active anti-tuberculosis compound (MICs: < 2 nM against the Mtb strains H37Rv, rRMP, and rINH).

Angiotensin III is an agonist of angiotensin 1 (AT1) and AT2 receptor.

Angiotensin II (3-8), human (TFA), is an angiotensin AT1 receptor agonist with reduced activity.

Anhydrosimvastatin (Dehydro simvastatin) is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.

Aniline-MPB-amino-C3-PBD is a cytotoxic agent with a non-alkylating group and acts as a sequence-selective DNA minor-groove binding agent.

Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and induces cell death on cancer cells.

Anti-parasitic agent 3 is effective against drug-resistant parasites.

T-1032 free base is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. It exhibits a relaxing effect on the isolated corpus cavernosum of rabbits. T-1032 free base is applicable for research into erectile dysfunction.

Erythromycin-D6 is a deuterated form of Erythromycin (TMSM-1118). Erythromycin, produced by actinomycetes, is a macrolide antibiotic (antibiotic) known for its broad antimicrobial activity. It functions by binding to the 50S ribosomal subunit of bacteria, thereby inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and/or translocation reactions, without affecting nucleic acid synthesis.

Erythromycin-D3 is the deuterated form of Erythromycin. Erythromycin, a macrolide antibiotic produced by actinomycetes, exhibits broad antibacterial activity. It works by binding to the 50S ribosomal subunit of bacteria, inhibiting RNA-dependent protein synthesis by blocking transpeptidation and/or translocation without affecting nucleic acid synthesis. Erythromycin (T1032) has shown antitumor properties and neuroprotective effects in various studies.

Erythromycin-13C-D3 is a 13C- and deuterated erythromycin that can be used to study the metabolic pathways of erythromycin in vivo.