Search Result

Search Results for " sting "

Targets

115

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11035	DiABZI STING agonist-1 (Tautomerism)	diABZI STING agonist (Compound 3)	STING
	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.		STING
T13015	STING agonist-4		STING
	STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).		STING
T8328	STING agonist-1	G10	Virus Protease , STING
	STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.		Virus Protease , STING
T9853	STING activator Compound 53		STING
	STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons...		STING
T9028	STING-IN-2	C-170	STING
	STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.		STING
T9029	STING-IN-3	C-171	STING
	STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.		STING
T5516	DiABZI STING agonist-1 trihydrochloride		STING
	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.		STING
T60000	STING (WT/R232) activity regulator 126		STING
	STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.		STING
T38161	STING Agonist C11	STING Agonist C11
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphory...
T74809	STING agonist-30		STING , Antifection
	STING agonist-30 is a potent STING agonist that triggers STING-dependent immune activation.STING agonist-30 shows broad-spectrum inhibitory effects against a variety of viruses including HSV (Herpes Simplex Virus), rotav...		STING , Antifection
T5154	C-176	C176,STING inhibitor 1	STING
	C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor		STING
T13014L	STING agonist-3 trihydrochloride	STING agonist-3 trihydrochloride (2138299-29-1 free base)	Others
	STING agonist-3 trihydrochloride is a selective and non-nucleotide agonist of small-molecule STING(pEC50 and pEC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatme...		Others
T38159	STING Agonist 12b
	STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 ...
T38160	STING Agonist 1a
	STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expres...
T13906	STING ligand-1		Others
	STING ligand-1 is a lead STING ligand(IC50 of 68 nM for HAQ STING).		Others
T13014	STING agonist-3		Others
	STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.		Others
T75161	STING agonist-31
	STING agonist-31, a potent STING agonist, exhibits EC50 values of 0.24 μM and 39.51 μM for human STING (h-STING) and murine STING (m-STING), respectively, demonstrating significant antitumor efficacy [1].
T74621	STING agonist-9
	STING Agonist-9 (Compound 45) is a powerful stimulator of the STING pathway, demonstrating potent activity with an EC50 of 1.2 nM against human STING (h-STING) and 32.82 μM against mouse STING (m-STING). It exhibits anti...
T63458	STING agonist-11
	STING agonist-11 is a potent activator of the small molecule cyclic urea class of STING (EC50: 18 nM).STING activation is a highly promising immunotherapy.
T72688	STING agonist-20
	STING agonist-20, a potent agonist utilized in the synthesis of XMT-2056, serves as a vaccine adjuvant for cancer and various inflammatory immune diseases research.
T81084	STING agonist-18
	STING Agonist-18 (Compound 1a) is a precursor for the synthesis of antibody-drug conjugates (ADCs), including Trastuzumab conjugates [1].
T61043	STING agonist-7
	STING agonist-7 is an agonist of non-nucleotide STING that binds selectively to mouse STING but not human STING [1].
T75094	STING agonist-26
	STING agonist-23 (CF508), a non-nucleotide small-molecule STING agonist, activates STING, thereby enhancing the phosphorylation of STING, TBK1, and IRF3. This activation elevates the production of IFN-β, IL-6, CXCL-10, T...
T74719	STING-IN-6
	STING-IN-6 (compound 50), a potent inhibitor of STING, exhibits a pIC50 value of 8.9, indicating its significant inhibitory capacity. This compound holds promise for research in immunity [1].
T74268	STING agonist-13
	STING Agonist-13, a stimulator of interferon genes (STING) agonist, enhances cancer immunity through STING-mediated immune activation. It activates STING downstream signaling to promote type I interferon immune responses...
T72615	STING modulator-4
	STING Modulator-4 is a competitive modulator of STING, exhibiting a K_i value of 0.0933 μM for the R232H STING variant. It demonstrates an EC_50 of over 10 μM for p-IRF3 activation in THP-1 cells.
T75011	STING-IN-5		STING
	STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis in macrophages, exhibiting an IC50 of 1.15 μM. T...		STING
T81083	STING agonist-19
	STING agonist-19 serves as a precursor for the synthesis of immune-stimulating antibody conjugates (ISACs).
T74718	STING modulator-5
	STING modulator-5 (compound 38), a STING modulator, exhibits a pIC50 value of 9.5 and antagonizes peripheral blood mononuclear cells (PBMC) with a pIC50 value of 8.1. Additionally, it acts as an antagonist of THP-1 cells...
T83841	STING Agonist D61	D61,Stimulator of Interferon Genes Agonist D61
	STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular as...
T63457	STING agonist-10
	STING agonist-10 is a potent activator of the STING small molecule cyclic urea class (EC50: 2600 nM).STING activation is a highly promising immunotherapy.
T75095	STING agonist-27
	STING agonist-27 (CF509) is a non-nucleotide, small-molecule agonist of STING, which activates STING and demonstrates activity against SARS-CoV series strains [1].
T75097	STING agonist-29
	STING agonist-29 (CF511) is a non-nucleotide small-molecule compound that acts as a STING agonist, effectively activating STING and demonstrating activity against SARS-CoV series strains [1].
T81082	STING-IN-7		STING
	STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of 11.5 nM. It effectively hampers the phosphorylation of both...		STING
T75092	STING agonist-24
	STING agonist-24 (CF504), a non-nucleotide small-molecule STING agonist, activates STING, leading to increased phosphorylation of STING, TBK1, and IRF3. It elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-...
T72614	STING modulator-3
	STING modulator-3 is a STING inhibitor that effectively inhibits R232 STING, exhibiting a Ki value of 43.1 nM in scintillation proximity assays. Despite its inhibitory action on R232 STING, it does not affect IRF-3 activ...
T75091	STING agonist-23
	STING agonist-23 (CF502) is a non-nucleotide, small-molecule stimulator of the STING pathway. Upon activation, it enhances the phosphorylation of STING, TBK1, and IRF3, leading to elevated levels of IFN-β, IL-6, CXCL-10,...
T75093	STING agonist-25
	STING agonist-23 (CF505) is a non-nucleotide, small-molecule compound that stimulates STING, enhancing the phosphorylation of STING, TBK1, and IRF3. It elevates the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and ...
T75096	STING agonist-28
	STING agonist-23 (CF510) is a non-nucleotide, small-molecule activator of the STING pathway. It initiates the phosphorylation of STING, TBK1, and IRF3, enhancing the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and...
T74267	STING agonist-17
	STING agonist-17 (compound 4a) is a highly potent stimulator of the STING pathway, exhibiting an IC 50 of 0.062 nM. It demonstrates significant anti-cancer properties, promoting tumor immunization [1].
T75090	STING agonist-22
	STING Agonist-22 (CF501) is a potent non-nucleotide STING agonist that functions as an adjuvant by activating STING to induce the type I interferon (IFN-I) response and the production of proinflammatory cytokines. It enh...
T83775	STING Agonist 12L	Stimulator of Interferon Genes Agonist 12L
	STING agonist 12L is a stimulator of interferon genes (STING) agonist that exhibits binding affinity for both wild-type STING and its variants R232, AQ, and Q with half-maximal inhibitory concentrations (IC50s) of 1.15 µ...
T74896	PROTAC STING Degrader-1
	PROTAC STING Degrader-1 (Compound SP23) is a STING-targeted PROTAC degrader exhibiting a DC50 of 3.2 μM and demonstrates anti-inflammatory activity [1].
T73746	DiABZI STING agonist-1
	DiABZI STING Agonist-1 is a selective receptor agonist for the stimulator of interferon genes (STING), demonstrating efficacy with EC50 values of 130 nM and 186 nM in human and mouse models, respectively.
T74328	STING agonist-8 dihydrochloride
	STING Agonist-8 Dihydrochloride (Compound 5-AB) is a highly effective STING agonist, exhibiting an EC50 value of 27 nM in THP1-Dual KI-hSTING-R232 cells.
T74676	STING agonist-20-Ala-amide-PEG2-C2-NH2
	STING agonist-20-Ala-amide-PEG2-C2-NH2, an active scaffolding molecule, engages the stimulator of interferon genes (STING) pathway and can be employed in the synthesis of immune-stimulating antibody conjugates (ISAC). Th...
T74677	STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
	STING Agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA, an active compound that interacts with the stimulator of interferon genes (STING), is utilized in the synthesis of immune-stimulating antibody conjugates (ISAC)....
T9119	SU0268		Others
	SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.		Others
T7329	C-178		STING
	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.		STING
T38162	STING18
	STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β productio...

Compounds

diABZI STING agonist-1 (Tautomerism)

T11035

Synonym: diABZI STING agonist (Compound 3)

Target: Virus Protease, STING

STING activator Compound 53

diABZI STING agonist-1 trihydrochloride

T5516

Synonym:

Target: STING

STING (WT/R232) activity regulator 126

Synonym: STING Agonist C11

Target: STING, Antifection

C-176

T5154

Synonym: C176,STING inhibitor 1

Target: STING

STING agonist-3 trihydrochloride

T13014L

Synonym: STING agonist-3 trihydrochloride (2138299-29-1 free base)

Synonym: D61,Stimulator of Interferon Genes Agonist D61

Synonym: Stimulator of Interferon Genes Agonist 12L

Target:

PROTAC STING Degrader-1

T74896

Synonym:

Target:

diABZI STING agonist-1

T73746

Synonym:

Target:

STING agonist-8 dihydrochloride

T74328

Synonym:

Target:

STING agonist-20-Ala-amide-PEG2-C2-NH2

T74676

Synonym:

Target:

STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA

Cat No.	Product Name	Synonyms	Targets
T10909	Cyclic-di-GMP	c-di-GMP,cyclic diguanylate,5GP-5GP	Others
	Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species.		Others
T72243	Cyclic-di-GMP diammonium	5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium
	Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species .
T64248	Cyclic-di-GMP sodium
	Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility and virulence of various bacteria.
T73717	CGAMP diammonium
	cGAMP (Cyclic GMP-AMPP) diammonium serves as an intrinsic second messenger in metazoans, initiating the production of interferons upon cytosolic DNA detection. It activates the stimulator of interferon genes (STING), sub...
T13606L	CGAMP disodium
	cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I inte...

Natural Products

Cyclic-di-GMP

T10909

Synonym: c-di-GMP,cyclic diguanylate,5GP-5GP

Target: Others

Cyclic-di-GMP diammonium

T72243

Synonym: 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01206	Sting Protein, Human, Recombinant (Sumo & His)	Human	E. coli
	Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a ...
TMPH-00067	Venom dipeptidyl peptidase 4 Protein, Apis mellifera, Recombinant (His & Myc)	Apis mellifera	E. coli
	Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process promelittin into its active form ...
TMPH-01836	Human Papilloma Virus type 18 (HPV 18) Protein E7 (E. coli, His)	HPV 18	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01838	Human Papilloma Virus type 52 (HPV 52) Protein E7 (His & SUMO)	HPV 52	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01837	Human Papilloma Virus type 18 (HPV 18) Protein E7 (His)	HPV 18	Yeast
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01834	Human Papilloma Virus type 16 (HPV 16) Protein E7 (His)	HPV 16	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01827	Human Papilloma Virus type 11 (HPV 11) Protein E7 (His & Myc)	HPV 11	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-00900	Human adenovirus C serotype 5 Early E1A protein (His & SUMO)	HAdV-5	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...