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Search Results for " s1p1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T28643 S1P1-IN-Ex26
S1P1-IN-Ex26 is a potent, selective antagonist of S1P1 receptor.
T16833 S1P1 Agonist III Others
S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).
T62732 S1P1 agonist 5
S1P1 agonist 5 is a selective, orally active S1P1 agonist. S1P1 agonist 5 inhibits the drainage of lymphocytes from lymphoid tissue into peripheral blood. S1P1 agonist 5 has potential for studies in multiple sclerosis (M...
T79816 S1P1 agonist 6 LPL Receptor
Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1].
T61639 S1P1 agonist 4
S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating a favorable pharmacological profile.
T79817 S1P1 agonist 6 hemicalcium LPL Receptor
Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as an immunosuppressive agent in researching a range of autoimmune diseases ...
T38716 SAR247799 SAR247799,S1P1 agonist 3
SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells a...
T28169 NIBR-0213 NIBR 0213 LPL Receptor
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
T3258 Ponesimod ACT-128800 S1P Receptor , LPL Receptor
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
T2026 CYM5442 S1P Receptor , LPL Receptor
CYM5442 is an S1P agonist, targeting to Sphingosine.
T6403 Siponimod BAF-312 S1P Receptor , LPL Receptor
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi...
T6923 Ozanimod RPC-1063 S1P Receptor , LPL Receptor
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero...
T2171 SEW​2871 SEW2871 S1P Receptor , LPL Receptor
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...
TQ0227 Etrasimod APD334 S1P Receptor , LPL Receptor
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
T22697 CS 2100 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid S1P Receptor
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.
T14924 Cenerimod ACT-334441 Others
Cenerimod (ACT-334441) is an agonist of sphingosine 1-phosphate 1 receptor (S1P1; EC50: 2.7 nM).
T10305 Amiselimod hydrochloride MT-1303 hydrochloride S1P Receptor , LPL Receptor
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T60204 W140 HBr S1P Receptor
[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM.
T7360 GSK2018682 S1P Receptor , LPL Receptor
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T15031 CYM50260 Others , LPL Receptor
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
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TargetMol