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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T28643 | S1P1-IN-Ex26 | ||
S1P1-IN-Ex26 is a potent, selective antagonist of S1P1 receptor. | |||
T16833 | S1P1 Agonist III | Others | |
S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM). | |||
T62732 | S1P1 agonist 5 | ||
S1P1 agonist 5 is a selective, orally active S1P1 agonist. S1P1 agonist 5 inhibits the drainage of lymphocytes from lymphoid tissue into peripheral blood. S1P1 agonist 5 has potential for studies in multiple sclerosis (M... | |||
T79816 | S1P1 agonist 6 | LPL Receptor | |
Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1]. | |||
T61639 | S1P1 agonist 4 | ||
S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating a favorable pharmacological profile. | |||
T79817 | S1P1 agonist 6 hemicalcium | LPL Receptor | |
Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as an immunosuppressive agent in researching a range of autoimmune diseases ... | |||
T38716 | SAR247799 | SAR247799,S1P1 agonist 3 | |
SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells a... | |||
T28169 | NIBR-0213 | NIBR 0213 | LPL Receptor |
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. | |||
T3258 | Ponesimod | ACT-128800 | S1P Receptor , LPL Receptor |
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity. | |||
T2026 | CYM5442 | S1P Receptor , LPL Receptor | |
CYM5442 is an S1P agonist, targeting to Sphingosine. | |||
T6403 | Siponimod | BAF-312 | S1P Receptor , LPL Receptor |
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi... | |||
T6923 | Ozanimod | RPC-1063 | S1P Receptor , LPL Receptor |
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero... | |||
T2171 | SEW2871 | SEW2871 | S1P Receptor , LPL Receptor |
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... | |||
TQ0227 | Etrasimod | APD334 | S1P Receptor , LPL Receptor |
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). | |||
T22697 | CS 2100 | 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid | S1P Receptor |
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist. | |||
T14924 | Cenerimod | ACT-334441 | Others |
Cenerimod (ACT-334441) is an agonist of sphingosine 1-phosphate 1 receptor (S1P1; EC50: 2.7 nM). | |||
T10305 | Amiselimod hydrochloride | MT-1303 hydrochloride | S1P Receptor , LPL Receptor |
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator. | |||
T60204 | W140 HBr | S1P Receptor | |
[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM. | |||
T7360 | GSK2018682 | S1P Receptor , LPL Receptor | |
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). | |||
T15031 | CYM50260 | Others , LPL Receptor | |
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |