mk-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9034	MK2-IN-3	MK2 Inhibitor III	MAPK
	MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis		MAPK
T12058	MK2-IN-3 hydrate	MK-2 Inhibitor III	ERK , MAPK , MNK
	MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)		ERK , MAPK , MNK
T1137	Clorsulon	L631529,MK401	ATPase , Antibiotic , Parasite
	Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep.		ATPase , Antibiotic , Parasite
T22988	MK-4827 Racemate	Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide	PARP
	MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1.		PARP
T15212	Emamectin Benzoate	MK-244	Apoptosis , Reactive Oxygen Species , GABA Receptor , Parasite
	Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.
T31813	Fludalanine	MK641,D-Alanine-2-d, 3-fluoro-,3-Fluoro-D-(2-2H)alanine
	Fludalanine (MK641), an analogue of D-alanine, irreversiably inactivates racemase and also inhibits synthase. When used in combination with cycloserine, it has been found to be more active against a variety of non-mycoba...
T4106	MK-8617	MK8617	HIF/HIF Prolyl-Hydroxylase
	MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).		HIF/HIF Prolyl-Hydroxylase
T2126	MK-5046		Bombesin Receptor
	MK-5046 is a novel BRS-3 agonist, binding to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).		Bombesin Receptor
T6032	Birabresib	OTX-015,OTX015 （MK 8628/Birabresib）,MK-8628	Epigenetic Reader Domain
	Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential antineoplastic activity.		Epigenetic Reader Domain
T16096	Filorexant	MK-6096	OX Receptor
	Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).		OX Receptor
T3700	SCH900776 (S-isomer)	MK-8776 S-isomer,SCH900776 S-isomer	Chk , CDK
	SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 16...		Chk , CDK
T13555	Ascr#2	Ascaroside C6	Others
	Ascr#2 (asc-C6-MK) is a glycoside analogue in Cryptococcus hidradii that promotes dauer formation.Ascr#2 mixtures with ascr#3 at low concentrations act as a male elicitor and can be used to detect population density.Ascr...		Others
T2650	MK-8245		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
	MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
T2517	SCH900776	MK 8776,MK-8776	Chk , CDK
	SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.		Chk , CDK
T6893	MK-886	MK886,L 663536	Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
	MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.		Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
T12062	MK-4074		Others
	MK-4074 is a liver-specific acetyl-CoA carboxylase ACC1 and ACC2 inhibitor(IC50 of 3 nM).		Others
T33439	MK-7725	MK7725
	Mk-7725 is an effective selective bombesin receptor subtype 3 agonist for the treatment of obesity.
T35052	Vibegron	MK4618,MK 4618,MK-4618
	Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).
T82414	Favezelimab	MK-4280
	Favezelimab (MK-4280) is a humanized anti-LAG-3 monoclonal antibody that inhibits the LAG-3/MHC class II interaction and shows potential for use in colorectal cancer (CRC) research, particularly when combined with the PD...
T38844	MK-8245 Trifluoroacetate
	MK-8245 trifluoroacetate is a phenoxy piperidine isoxazole derivative functioning as a potent, liver-targeting stearoyl-CoA desaturase (SCD) inhibitor, demonstrating significant anti-diabetic and anti-dyslipidemic effect...