5-ht1e

BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values: 8.7 and 8.9, respectively).

SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders.

LY 344864 hydrochloride is a selective receptor agonist with an affinity of 6 nM (Ki) at the 5-HT1F receptor.

SB 243213 hydrochloride is an orally active, selective, high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor (pKi of 9.37 and pKb of 9.8), with an improved anxiolytic profile and potential for treating schizophrenia and motor disorders.

SB 243213 dihydrochloride is an orally active, selective, and high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor, with a pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor.

LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.

SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. It increases extracellular aspartate and glutamate in the frontal cortex and exhibits anticonvulsant activity (EC50: 0.16 μM).

SB 224289 is a selective antagonist of 5-HT1B receptor with pKi of 8.2. It is a centrally active following oral administration in vivo. SB 224289 displays 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand

L-694,247 is a selective 5-HT receptor agonist with affinity for 5-HT1D, 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1E receptors, and can be used to study neurological diseases.

L694247 (TFA) is a specific agonist of the 5-HT1D receptor, with pIC50 values of 10.03, 8.64, 6.42, and 5.66 for the 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors, respectively.

4-AcO-DALT hydrochloride is a psychoactive tryptamine compound. It acts as an inhibitor of multiple receptors, including 5-HT receptors, α receptors, dopamine receptors (dopamine receptors), histamine receptor 1 (H1), muscarinic M2 receptor (muscarinic M2 receptor), and Sigma 2 receptor. The compound exhibits Ki values for various receptors: 582 nM for 5-HT1B, 2689 nM for 5-HT1D, 2099 nM for 5-HT1E, 2116 nM for 5-HT2A, 958 nM for 5-HT2B, 137 nM for 5-HT2C, 824 nM for 5-HT6, 479 nM for 5-HT7A, 406 nM for H1, 874 nM for Sigma 2, 4190 nM for α2A, 482 nM for α2B, 214 nM for α2C, 803 nM for D2, 4522 nM for D3, and 1907 nM for D3.

BRL 54443 (MALEATE) is a potent agonist for the 5-HT1E/1F receptors, exhibiting Ki values of 1.1 nM and 0.7 nM, respectively. It is over 30 times more selective in its affinity for these receptors than for other serotonin (5-HT) and dopamine receptors.