3 β-hydroxysteroid dehydrogenase/delta 5-->4-isomerase

Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.

Trilostane-D3 is a deuterium-substituted isotope-labeled compound of Trilostane (T1473), which is used primarily as a quantitative tracer. Trilostane is a competitive and specific inhibitor of 3-beta-hydroxysteroid dehydrogenase (3β-HSD), with the advantage of oral activity. Trilostane reduces the synthesis of steroid hormones by inhibiting the activity of 3β-HSD, and can be used in studies of Cushing's syndrome (hypercortisolism), Con's syndrome (hyperaldosteronism), and postmenopausal breast cancer.