2' deoxyadenosine

2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.5 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Key steps in nucleotide biosynthesis are regulated by feedback inhibitionBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.DNA is replicated by polymerases that take instructions from templatesBiochemistry(2002) 3.Cadwell, R.C., and Joyce, G.F.Randomization of genes by PCR mutagenesisPCR Methods Appl.2(1)28-33(1992) 4.Steffens, D.L., Jang, G.Y., Sutter, S.L., et al.An infrared fluorescent dATP for labeling DNAGenome Res.5(4)393-399(1995) 5.Flinn, A.M., and Gennery, A.R.Adenosine deaminase deficiency: A reviewOrphanet J. Rare Dis.13(1)65(2018)

N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.

2'-Chloro-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2'-Modified nucleoside.

2-Bromo-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2-Modified purine nucleoside; Scaffold and Template.

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyadenosine is a Nucleoside Derivative - Protected nucleoside with NH2/OH open.

3'-O-(t-Butyldimethylsilyl)-2'-deoxyadenosine is a Nucleoside Derivative - Protected nucleoside with NH2/OH group open.

Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, demonstrates potent activity against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity.

N6-Etheno 2'-deoxyadenosine is used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.

3-Deaza-2'-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM. This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

2-Methoxy-2'-deoxyadenosine is a Nucleoside Derivative - 2-Modified purine nucleoside.

8-Bromo-2'-deoxyadenosine is a 2'-deoxynucleoside and halo-nucleoside.

N6-Benzoyl-2'-chloro-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2'-Modified nucleoside.

8-Chloro-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside, 8-Modified purine nucleoside.

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite, an adenine nucleoside analog, has potential vasodilator and anticancer activities relevant to cancer research.

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-2'-deoxyadenosine is a nucleoside derivative with an open NH2/OH group.

N6-Isopentenyl-2'-deoxyadenosine is a Nucleoside Derivative - 6-Modified purine nucleoside.

2-Methyl-2'-deoxyadenosine is a Nucleoside Derivative - 2-Modified purine nucleoside.

8-Methyl-2'-deoxyadenosine is a Nucleoside Derivative - 8-Modified purine nucleoside.

5'-O-DMTr-N6-ethyl-2'-deoxyadenosine 3'-CED phosphoramidite is a Nucleoside Phosphoramidite.

2-Chloro-N6-methyl-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside, 2-Modified purine nucleoside, 6-Modified purine nucleoside.

2-Chloro-N6,N6-dimethyl-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside, 2-Modified purine nucleoside, 6-Modified purine nucleoside.

2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.

2'-Amino-2'-deoxyadenosine-5'-O-diphosphate (2'-NH2-ADP) sodium is an amine-modified nucleotide, serving as a structural analog of the purine nucleotide ADP.