γ-glutamyltransferase

γ-glutamyltransferase (GGT) is an enzyme located on the outer surface of the cell membrane. It maintains physiological concentrations of intracellular glutathione and cellular defense against oxidative stress by cleaving extracellular glutathione and increasing the availability of amino acids. γ-glutamyltransferase can be utilized as a biomaterial or organic compound in life science-related research.

GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits

γ-GT (H-GLA(PNA)-OH) is used as a synthetic substrate for gamma-glutamyltransferase (GGT) to determine GGT activity.

Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting glutamyltransferase, inducing reactive oxygen species accumulation, compromising cell membranes, and disrupting histone acetylation processes [1].

Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting glutamyltransferase, inducing reactive oxygen species accumulation, disrupting cell membranes, and dysregulating histone acetylation [1].

GGsTop (Nahlsgen) is a highly selective and irreversible inhibitor of γ-glutamyltransferase (GGT) with antiaging activity.

Acivicin hydrochloride is the hydrochloride form of Acivicin (AT125, U42126).Acivicin, a natural product from Streptomyces sviceus (Streptomyces), is a glutamine analog and a potent inhibitor of γ-glutamyltransferase (GGT) and a potent inhibitor of l -Asparagine synthetase and other l-glutamine aminotransferases, and is cytotoxic by blocking nucleotide biosynthesis.