β-ctf

Timosaponin BII (Prototimosaponin A III) exhibits anti-dementia and antioxidant activities, with potential applications in treating type 2 diabetes. It can inhibit the up-regulation of BACE1 and reduce the over-production of β-CTF and Aβ in rat retina induced by FeCl.

Tat-NR2B9c TFA is a 20-aa peptide, and acts as an inhibitor of postsynaptic density-95 (PSD-95)(EC50 of 6.7 nM for PSD-95d2), and possesses neuroprotective efficacy.

(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to create PROTACs (e.g., GMB-475), which effectively induce the degradation of BCR-ABL1, demonstrated by an IC50 of 1.11 μM in Ba/F3 cells.

MMC(TMZ)-TOC TFA exhibits high binding affinity and selectivity for the somatostatin receptor subtype 2 (SSTR2). It targets the delivery of TMZ to SSTR2-positive tumor cells, making MMC(TMZ)-TOC TFA useful for cancer research.

2C-TFM hydrochloride is a chemical compound classified as a 2,5-dimethoxyphenethylamine with a para-trifluoromethyl substitution. It acts as a potent agonist for the 5-HT receptor subtypes 5-HT2A and 5-HT2C.

PA-Nic TFA is a photoreactive nicotine compound that releases nicotine efficiently when subjected to photolysis by a laser at approximately 405 nm.

Ianthelliformisamine C TFA, an antibiotic enhancer, is used to against resistant Gram-negative bacteria.

PSMA617-TCMC is a derivative of PSMA-617 with structure modification, in which the caroboxy groups in DOTA ring is replaced by TCMC macrocycle. PSMA-617 is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer.

Boc-LRR-AMC TFA is a fluorescent protease substrate used to detect the trypsin-like activity of the 26S proteasome or 20S proteasome core.

H-β-Ala-AMC TFA is a substrate for aminopeptidase and serves as a building block for synthesizing the fluorogenic vanin I substrate [pantothenate-AMC].

ω-Conotoxin MVIIC TFA is a peptide and neurotoxin with 26 residues that preferentially blocks P-type and Q-type Ca ++ currents by binding with high affinity to voltage-sensitive neuronal Ca ++ channels (VGCCs) and can be radiolabeled and used in immunoprecipitation assays.

N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases, which releases free AMC upon protease cleavage. Its excitation/emission wavelengths are 380/460 nm, and it can be used to assess the activity of trypsin, plasmin, and cathepsin.

CTTHWGFTLC, also known as CYCLIC TFA, is a cyclic peptide that acts as an inhibitor of matrix metalloproteinases (MMP-2 and MMP-9), with an IC50 value of approximately 8 μM for MMP-9 [1].

Omiganan-FITC TFA, a compound integrating the bactericidal and fungicidal cationic peptide Omiganan with a fluorescein isothiocyanate (FITC), is under development as a topical gel aimed at preventing catheter-associated infections [1].

Ac-WEHD-AFC TFA is a fluorogenic substrate for caspase-1, used to measure the enzyme's activity in tumor and inflammation research [1].

Dovitinib RIBOTAC TFA effectively and selectively cleaves pre-miR-21, functioning as a targeted RNA degrader.

Pyr-Arg-Thr-Lys-Arg-AMC TFA, an AMC-tagged decapeptide, is selectively cleaved by proteases such as trypsin and thrombin, serving as a substrate for measuring protease activity and assessing enzyme inhibitor efficacy [1].

Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) is a thrombin-specific fluorogenic substrate used to assess thrombin generation in platelet-rich plasma (PRP) and platelet-poor plasma (PPP).

EWFW-ACC TFA is a specific immunoproteasome substrate used for studying immunoproteasome functions.

iso-VQA-ACC TFA is a substrate of the constitutive proteasome.

Boc-GRR-AMC (TFA) is a tripeptide substrate utilized in fluorescence assays to analyze substrate specificity of West Nile virus (WNV) NS2B-NS3 protease or to determine the optimal pH for LdMC activity.

Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA serves as a fluorescent substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). Upon enzymatic cleavage, AMC is released, and its fluorescence allows for the quantification of the trypsin-like activity of the 26S proteasome.

Bz-FVR-AMC TFA is a fluorescent substrate for cathepsin, with a kcat/Km value of 1070 mM^-1s^-1. At high concentrations, Bz-FVR-AMC acts as an inhibitor to the substrate.

LDV-FITC TFA is a fluorescent peptide, specifically an FITC-conjugated LDV peptide. This compound binds to the α4β1 integrin with high affinity, displaying a Kd of 0.3 nM in the presence of Mn2+ and 12 nM in its absence, when binding to U937 cells. LDV-FITC TFA is useful for assessing α4β1 integrin affinity.