Oroxylum

1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.

Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.

Lup-20(29)-ene-2alpha,3beta-diol is a natural product of Oroxylum, Bignoniaceae. The catalog number is TN4460 and the CAS number is 61448-03-1. Lup-20(29)-ene-2alpha,3beta-diol can be used as a reference standard.

5-Hydroxy-7-acetoxyflavone is a natural product from Oroxylum indicum.

5,7-Diacetoxyflavone is a flavonoid discovered in Dolichandrone falcata, with anti-cancer activity, and its IC50 values for SGC-7901 and HT-29 cells are 4.5 µM and 2.6 µM respectively.