Epimedium

Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-inflammatory and antibacterial activities, and may have scavenging activity against DPPH radicals, inhibiting the proliferation of MCF-7 and HepG2 in a dose-dependent manner. Epimedokoreanin B also exhibits anti-inflammatory and antibacterial activity, with DPPH radical scavenging activity, and inhibits the proliferation of MCF-7 and HepG2 in a dose-dependent manner.Epimedokoreanin B significantly inhibits the formation of N (α)-(carboxymethyl)lysine (CML) and N (Ï)-(carboxymethyl)arginine (CMA), and prevents clinical complications of diabetes mellitus through the inhibition of advanced glycation end-products (AGEs).

Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.

Epimedin A has anti-osteoporosis activities in vivo.

Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling. Icaritin at low concentration (4 or 8 μMol/L) can promote rat chondrocyte proliferation and inhibit cell apoptosis, while the effect of Icaritin on rat chondrocyte at high concentration was reversed.

Icariin (Ieariline) belongs to the flavonol glycoside group of natural products, can inhibit PDE5 and PDE4 activity (IC50=432/73.50 μM), is also a PPARα activator. Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoiesis, immunity and bone metabolism.

Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.

Epimedin A1 (Hexandraside F)(Hexandraside F) is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines.

Isoanhydroicaritin is a naturally occurring flavonoid that inhibits physiological melanin synthesis and recovery and inhibits mushroom tyrosinase.

1. Epimedin B (Epmedin B) has potential activity against osteoporosis by stimulating osteoblasts.

Epimedoside A has significant antioxidant activity in vitro.

Noricaritin, a flavonoid derived from Epimedium root, induces cell proliferation in lung tissue and inhibits the production of pro-inflammatory cytokines and chemokines in human lung epithelial cells.

1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical properties of vertebrae, without any stimulation on uterus. 3. β-Anhydroicaritin possesses significant protective effects on the zymosan-induced peritonitis mice, which might be associated with the regulation of Ca(2+); influx in macrophages and iNOS expression.

Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteoporosis by stimulating osteoblasts.

Sagittatoside A (Icariin-A) is a flavonoid glycoside that can be extracted from Herba Epimedii. It induces the phosphorylation of serine 118 in the ERα, selectively activating estrogen response elements (ERE) and luciferase activity.

2''-O-Rhamnosylicariside II is beneficial for improving postmenopausal osteoporosis and demonstrates potent antioxidant activity, with IC50 values of 90.5 µM [90.5 uM].

IKarisoside A(Baohuoside II) is a flavonol glycoside from the Berberidaceae plant Epimedium, with anti-inflammatory activity.

Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.

8,3'-Diprenylapigenin is a natural product for research related to life sciences. The catalog number is TN3264 and the CAS number is 955135-37-2.

Sagittatoside C is a natural product

Icariside E5 may have antioxidant property that strengthen the importance of peppers in the Mediterranean diet.

Epimedin K is a natural product from Epimedium koreanum NAKAI (Berberidaceae).

Epimedin B1 is a natural product for research related to life sciences. The catalog number is TN3970 and the CAS number is 133137-58-3.

Korepimedoside A is a natural product from Epimedium koreanum.

Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level.