Dipsacus

Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.

Dipsacoside B, a major bioactive saponin, is used as a marker.

Dipsanoside A is a novel tetracyclic glycoside glucoside and cyclic enol ether terpene extracted from Dipsacus asper, which has anti-osteoporotic effects and promotes osteoblast division.

Dipsacus saponin X is a triterpenoid saponin derived from Dipsacus asper. It stimulates the proliferation of UMR106 cells and increases alkaline phosphatase（ALP） activity. Additionally, it exhibits anti-acetylcholinesterase（AChE) activity, suggesting potential neuroprotective effects.

Sylvestroside I exhibits antibacterial activity and inhibits Staphylococcus epidermidis, Pseudomonas aeruginosa ATCC, Escherichia coli, and Enterococcus faecalis ATCC 1054.

Dipsanoside B is a novel tetrairidoid glucoside isolated from Dipsacus asper Wall., a perennial plant widespread in China that has been used in traditional Chinese medicine for hundreds of years. Dipsanoside B is historically employed as a tonic for refreshment, as a fissiparism promoter of osseous cells to support bone health, and as an embryo security agent.

Cantleyoside, a natural cyclic enol ether terpene glycoside from Pterocephalus hookeri, has anti-inflammatory and pro-apoptotic effects, inhibiting inflammatory responses and promoting apoptosis in HFLS-RA cells through activation of the AMPK/Sirt1/NF-κB signaling pathway.

Cauloside A is a bioactive triterpenoid saponin derived from Cimicifuga thalictroides with multifunctional anti-inflammatory, antimicrobial, cytotoxic, hemolytic, and molluscicidal activities. Cauloside A induces concentration-dependent and time-dependent mitochondriotoxic actions, rapidly increasing the cellular respiration rate followed by a dramatic decline within minutes. Mechanistic studies show Cauloside A disrupts mitochondrial membrane integrity, impairing mitochondrial function and contributing to potent biological effects relevant to therapeutic development.

Asperosaponin IV is a natural product for research related to life sciences. The catalog number is TN5282 and the CAS number is 126778-93-6.