Caprifoliaceae

Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.

Dipsacoside B, a major bioactive saponin, is used as a marker.

Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agents for the HTC hepatoma cells. Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety.

Dipsanoside A is a novel tetracyclic glycoside glucoside and cyclic enol ether terpene extracted from Dipsacus asper, which has anti-osteoporotic effects and promotes osteoblast division.

1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the

Dipsacus saponin X is a triterpenoid saponin derived from Dipsacus asper. It stimulates the proliferation of UMR106 cells and increases alkaline phosphatase（ALP） activity. Additionally, it exhibits anti-acetylcholinesterase（AChE) activity, suggesting potential neuroprotective effects.

Sylvestroside I exhibits antibacterial activity and inhibits Staphylococcus epidermidis, Pseudomonas aeruginosa ATCC, Escherichia coli, and Enterococcus faecalis ATCC 1054.

Dipsanoside B is a novel tetrairidoid glucoside isolated from Dipsacus asper Wall., a perennial plant widespread in China that has been used in traditional Chinese medicine for hundreds of years. Dipsanoside B is historically employed as a tonic for refreshment, as a fissiparism promoter of osseous cells to support bone health, and as an embryo security agent.

Cantleyoside, a natural cyclic enol ether terpene glycoside from Pterocephalus hookeri, has anti-inflammatory and pro-apoptotic effects, inhibiting inflammatory responses and promoting apoptosis in HFLS-RA cells through activation of the AMPK/Sirt1/NF-κB signaling pathway.

Nardosinonediol (Tetrahydronardosinon) is a natural compound derived from Nardostachys jatamansi that acts as a serotonin transporter (SERT) inhibitor, regulating serotonin levels and thus exerting antidepressant effects.

Kanshone A, a sesquiterpenoid naturally derived from Nardostachys chinensis, is cytotoxic and inhibits the proliferation of P-388 leukemia cells.

Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities, inhibits NF-B and MAPK-mediated inflammatory pathways, and attenuates ovx-induced osteoclastogenesis and bone loss.

Hydroxyvalerenic acid is a natural product

Nardoaristolone B, a nor-sesquiterpenoid with an unusual fused ring system and having protective effects on the injury of neonatal rat cardiomyocytes. The novel mosquito-repellentsynthetic hydrindanesbased on noreremophilanes and nardoaristolone B which s

Volvalerenic acid A is a natural product

Heishuixiecaoline A protects against neurotoxicity in PC12 cells.

Homobaldrinal has low toxic activity. It has genotoxic activity in the Salmonella/microsome test and the SOS-chromotest.

Valeriotetrate C is a natural product from Valeriana jatamansi.

Valtrate Hydrine B4 is a natural product demonstrating anti-leishmaniasis activity.

Valechlorine is a natural product isolated from Valeriana officinalis, applicable for biochemical experiments and drug synthesis research.

Jatamanvaltrate B shows cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8),and hepatoma (Bel7402) cell lines.

Kanshone B shows inhibitory activity against LPS-induced NO production with the IC(50) value of 4.6-21.6 uM.

Narchinol B shows inhibitory activity against LPS-induced NO production.

Valeriotriate B is a natural product for research related to life sciences. The catalog number is TN5553 and the CAS number is 862255-64-9.