Coffea

Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.

3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.

Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.

5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist and a potential lead compound for further testing in the drug development process for aging-associated diseases.

4-O-Feruloylquinic acid can be useful for the prevention of cardiovascular and other chronic diseases.

CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.

1-Phenylpropane-1,2-dione (Acetyl benzoyl) is a eukaryotic metabolite produced in plant metabolic reactions.

Cafedrine (Cafedrin) is found in tea and coffee and has a central nervous system stimulant effect.Cafedrine is often used in a 20:1 combination with a fixed dose of cortisone in the study of acute hypotension.

4'-Hydroxy-3'-methylacetophenone is a phenolic volatile natural product isolated from raw coffee beans (Coffea Arabica L.) in Hawaii. 4'-Hydroxy-3'-methylacetophenone exhibits potent antioxidant activity, comparable to that of other phenolic volatile compounds such as thymol and eugenol. 4'-Hydroxy-3'-methylacetophenone is a key intermediate in organic synthesis and can be used to construct heterocyclic compounds with anti-mycobacterial activity.