Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.
Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco, acting as a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. It depolarizes TE671 cells that endogenously express human myotypic nAChRs.
(S)-(-)-Anatabine ((-)-Anatabine), an alkaloid present in tobacco, is an NRF2 activator that attenuates ovalbumin-induced asthma through oxidative stress and inflammation mitigation as well as up-regulation of Nrf2 HO-1 signaling in rats, and may be used in the study of autoimmune thyroiditis.
4-Methyl-1-pentanol exhibits inhibitory activity against SCC-25 cells and NHK cells (normal human keratinocytes), making it useful for cancer research.
Cyclopent-4-ene-1,3-dione is a highly reactive cyclic diketone organic compound that has been employed as a key synthetic intermediate in the laboratory synthesis of more complex molecules, including 2-methoxymethylene-Cyclopent-4-ene-1,3-dione and the natural product derivative chrysotrione B (a 2-acylcyclopentene-1,3-dione derivative), Cyclopent-4-ene-1,3-dione was historically used to investigate the influence of sulfhydryl group-specific chemical reagents on the activity of bovine heart phospholipid exchange protein.