T14363 |
AZ-23
|
915720-21-7
|
98%
|
|
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM,...
|
T17169 |
Trk-IN-4
|
1799788-94-5
|
98%
|
|
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
|
T17170 |
PF-06737007
|
1863905-38-7
|
98%
|
|
PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).
|
T17000 |
Tavilermide
|
263251-78-1
|
98%
|
|
Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic.
|
TN2890 |
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one
|
244277-75-6
|
98%
|
|
Standard reference
|
T13207 |
PF-06733804
|
1873373-33-1
|
98%
|
|
PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
|
T13208 |
TrkA-IN-1
|
1680179-43-4
|
98%
|
|
TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.
|
T41224 |
CG 428
|
2412055-93-5
|
98%
|
|
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 jo...
|
T5995 |
Larotrectinib
|
1223403-58-4
|
98%
|
|
Larotrectinib is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).
|
T9292 |
ALE-0540
|
234779-34-1
|
98%
|
|
ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediate...
|
T9496 |
LOXO-195
|
1350884-56-8
|
98%
|
|
(6RS)-LOXO-195 is a potent and selective Trk tyrosine kinase inhibitor.
|
T6712 |
Tyrphostin AG 879
|
148741-30-4
|
98%
|
|
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
|
T7568 |
LM22A-4
|
37988-18-4
|
98%
|
|
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anis...
|
T5635 |
CH7057288
|
2095616-82-1
|
98%
|
|
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
|
T1704 |
Diosmetin
|
520-34-3
|
98%
|
|
Diosmetin has been found to act as a weak TrkB receptor agonist.
|
T19649 |
PF-06273340
|
1402438-74-7
|
98%
|
|
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metab...
|
T4496 |
LM22B-10
|
342777-54-2
|
98%
|
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
|
T8327 |
ONO-7475
|
1646839-59-9
|
98%
|
|
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
|
T2094 |
Danusertib
|
827318-97-8
|
98%
|
|
Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may ...
|
T2349 |
BMS-754807
|
1001350-96-4
|
98%
|
|
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine ...
|