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IDO

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is a heme-containing enzyme physiologically expressed in several tissues and cells, such as the small intestine, lungs, female genital tract or placenta.IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.

  • Epacadostat
    T35481204669-58-8
    Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells.
    • $39
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  • IDO1-IN-1
    T20513615-21-4
    IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
    • $50
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  • IDO-IN-12
    T116151888341-29-4In house
    IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
    • $98
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  • PF-06840003
    T4307198474-05-4
    PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.
    • $38
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  • IDO1-IN-5
    T119012166616-75-5
    IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
    • $34
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  • Kushenol E
    T821499119-72-9
    Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity.
    • $261
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  • IACS-8968 R-enantiomer
    T116272239305-67-8
    IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
    • $1,520
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  • β-Lapachone
    T64074707-32-8
    β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
    • $40
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    TargetMol | Citations Cited
  • IDO-IN-6
    T116201402837-76-6
    IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
    • $1,190
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  • IDO-IN-11
    T116141888378-32-2
    IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
    • $1,980
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  • IDO-IN-13
    T116162291164-02-6
    IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
    • $88
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  • IACS-8968
    T116262144425-14-7
    IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
    • $1,670
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  • IDO-IN-8
    T116211402837-77-7
    IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
    • $1,190
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  • IDO-IN-9
    T116221888378-12-8
    IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
    • $1,820
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  • IDO-IN-3
    T116172070018-30-1
    IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
    • $227
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  • IDO1-IN-2
    T116242346614-58-0
    IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
    • $1,520
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  • IACS-8968 S-enantiomer
    T116282239305-70-3
    IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
    • $1,520
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  • IDO-IN-5
    T116191402837-79-9
    IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
    • $1,190
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  • GNF-PF-3777
    T1019977603-42-0
    GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
    • $46
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  • IDO5L
    T2647914471-09-3
    IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
    • $43
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  • BMS-986242
    T91641923844-48-7
    BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
    • $175
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  • Linrodostat
    T45321923833-60-6
    Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
    • $52
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