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ys-49 monohydrate

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YS-49 monohydrate
T75238
YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA PTEN in 3-methylcholanthrene-treated cells. It also prevents the angiotensin II (Ang II)-induced proliferation of vascular smooth muscle cells (VSMCs) by promoting the expression of heme oxygenase (HO)-1. Additionally, YS-49 exerts a significant positive inotropic effect by stimulating cardiac β-adrenoceptors, showcasing its multifaceted pharmacological activities [1] [2] [3].
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YS-49 monohydrate (132836-42-1 free base)
YS-49 monohydrate
T13376L
YS-49 (monohydrate) is an activator of PI3K Akt (a downstream target of RhoA).
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6-8 weeks
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