utrophin

ART-CHEM-BB B025267 is the upregulator of utrophin production with EC50 of 1.8 μM and can be used in research on the treatment of Duchenne muscular dystrophy.

Utrophin Modulator 1 (UM1) is a highly effective agent that upregulates utrophin protein levels, displaying an EC 50 of 0.11 μM. Its application in the investigation of Duchenne Muscular Dystrophy (DMD) has been well-established [1].

AHR antagonist 8 (compound SG-02) acts as a regulator of utrophin, a dystrophin analog, and serves as an AhR antagonist with a Kd of 41.68 nM. Studies demonstrate that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. Additionally, AHR antagonist 8 enhances MyHC expression, indicating its potential to promote myogenesis. ADME evaluations reveal that AHR antagonist 8 possesses some oral bioavailability.

Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and protein. Through this action, Ezutromid increases muscle function in dystrophin-deficient MDX mice, a mouse model of muscular dystrophy.

OX01914 is a water-soluble and permeable modulator of utrophin that upregulates utrophin protein levels with an EC50 of 20.5 μM. OX01914 can be used in Duchenne muscular dystrophy (DMD) studies [1].