usp10

Spautin-1 is an autophagy inhibitor that suppresses the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Spautin-1 inhibits UPR and exhibits preferential cytotoxicity in glucose-starved cancer cells.

Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.

USP10-IN-3 (compound D1) is a potent inhibitor of USP10, with an IC50 of 7.2 µM. It can suppress cell proliferation, induce apoptosis, and cause cell cycle arrest in the S phase.

USP10-IN-4 is a potent inhibitor of ubiquitin-specific protease 10 (USP10), with an IC50 of 10.87 μM and a Kd of 365 nM. It effectively inhibits USP10-mediated proteasomal degradation of downstream proteins YAP and p53, leading to the downregulation of CDK4 in the p53 signaling pathway. USP10-IN-4 promotes apoptosis in liver cancer cells (apoptosis) and inhibits the initiation and progression of liver cancer. It is applicable in the study of hepatocellular carcinoma (HCC).

WW-104 is a selective USP10 inhibitor with an IC50 of 16.75 μM and a Kd of 237 nM. It can induce G2 phase arrest and apoptosis (Apoptosis) and exhibits significant antiproliferative effects on cell lines overexpressing USP10. Additionally, WW-104 demonstrates anticancer activity against hepatocellular carcinoma.