uricosuric

Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

Acetic acid, 2-[4-[(2-ethyl-3-benzofuranyl)carbonyl]phenoxy]- is a compound used for antiviral activity determinations.

Irtemazole (R 60844) is a novel uricosuric substance that is valuable in the treatment of hyperuricemia and gout.

Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity

Etebenecid (Urelim) is uricosuric agents, which lower uric acid levels in the body by increasing the elimination of uric acid by the kidneys. It also inhibits penicillin tubular secretion.

Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.

Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.

Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).

Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering

Epaminurad (UR-1102) is an orally active, potent, and selective URAT1 (urate transporter 1) inhibitor with a Ki of 0.057 μM, and it inhibits OAT1 and OAT3 (organic anion transporter) modestly. Epaminurad is a uricosuric agent used for research on gout and hyperuricemia [1].

Difenpiramide is a non-steroidal anti-inflammatory drug (NSAID) related to the research of degenerative and inflammatory arthropathies. Research shows Difenpiramide demonstrated anti-inflammatory effects comparable to indomethacin and phenylbutazone, with additional peripheral analgesic, antipyretic, and uricosuric activities. Difenpiramide inhibits prostaglandin synthesis and inflammatory mediators without affecting platelet aggregation or coagulation, and its therapeutic index was found to be more favorable than reference NSAIDs.

S 8666 is a potent diuretic with uricosuric action.