tubulin polymerization-in-18

Tubulin aggregation-IN-18 (compound 3) is a potent tubulin aggregation inhibitor with potential for breast cancer and drug-resistant colon cancer studies.

Tubulin inhibitor 49 (Compound 18) is a tubulin polymerization inhibitor (IC50 = 48 μM) that disrupts the cellular microtubule network, arresting the cell cycle at G2 phase. It exhibits toxicity toward HeLa cells (IC50 = 8.8 μM).

Tubulin inhibitor 49 (Compound 18) hydrobromide is a tubulin polymerization inhibitor with an IC50 of 48 μM. It effectively disrupts the cellular microtubule network, arrests the cell cycle in the G2 phase, and exhibits cytotoxicity with an IC50 of 8.8 μM in HeLa cells. This compound is applicable in cervical cancer research.

Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity. Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631 PMID:21609844 |Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 18 679 PMID:21700202