tnk1

Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).

Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).

Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and 'normal' cells.

XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).

TP-5801 is an orally active non-receptor tyrosine kinase (TNK1) inhibitor with an IC50 of 1.40 nM and exhibits antitumor effects.

TP-5801 TFA is an orally active inhibitor of TNK1, a non-receptor tyrosine kinase, with an IC50 of 1.40 nM, demonstrating anti-tumor activity [1].