tnfα-induced cytotoxicity

Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TNFα increases the cytotoxicity of T cells.

C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.

iNUB is a selective small-molecule inhibitor of NEMO–ubiquitin binding that suppresses TNFα-induced NF-κB signaling, while exhibiting selective cytotoxicity toward IKK/NF-κB–dependent activated B-cell–like diffuse large B-cell lymphoma (ABC-DLBCL), making it a valuable research tool for dissecting NF-κB pathway dependency and targeted cancer signaling vulnerabilities.