tmem16a chloride channel

(+)-Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. (+)-Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.

T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated chloride channel (CaCC).

Eact is a selective and potent TMEM16A activator that directly activates the TRPV1 channels in sensory nociceptors, thereby producing itch, acute nociception, and thermal hypersensitivity (brackets).

ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.

TMEM16A modulator-1 (compound 36) is a positive modulator of calcium-activated chloride channel (CaCC) TMEM16A. It is useful for research associated with TMEM16A-related diseases, particularly in studying respiratory system diseases and conditions.

Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the treatment of ancer, hypertension, pain, diarrhea and asthma.

CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).

(±)-Liquiritigenin ((±)-4',7-Dihydroxyflavanone), a flavonoid extracted from Angelica keiskei, inhibits the calcium-activated chloride channel TMEM16A.(±)-Liquiritigenin induces an increase in apoptosis and an enhancement of caspase3 activity. (±)-Liquiritigenin induces increased apoptosis and enhanced caspase3 activity. (±)-Liquiritigenin is used in breast cancer research.

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.

Anti-ANO1/TMEM16A Antibody is a potent tool antibody targeting the calcium-activated chloride channel ANO1, utilized for investigating functional interactions between ion channels and receptor tyrosine kinases (RTKs). The compound specifically recognizes the ANO1 protein, revealing how its physical complex with the epidermal growth factor receptor (EGFR) synergistically regulates downstream signaling cascades, aiming to modulate tumor cell proliferation and survival potential by intervening in this interaction.

(+)-Shikonin (Standard) is a reference standard for research and analysis in studies involving (+)-Shikonin. (+)-Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.