thiosemicarbazone

BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.

Acetophenone, 5'-amino-2'-(octyloxy)-, thiosemicarbazone is a bioactive chemical.

Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV), exhibiting antiviral activity against both HSV-1 and HSV-2. Moreover, it is an effective anti-poxvirus agent for the treatment of monkeypox, orthopox, and cowpox viruses.

Indium (III) thiosemicarbazone 5b is an anticancer compound demonstrating cytotoxicity against various cancer cell lines including A549, MCF-7 breast, cisplatin-resistant MCF-7/DDP breast, and Hl 7702 liver cancer cells, with IC50 values of 2.41, 1.97, 2.11, and 8.95 µM, respectively. It effectively lowers PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo studies show that at a dosage of 2.5 µmol/kg, indium (III) thiosemicarbazone 5b significantly reduces tumor weight and volume in MCF-7/DDP mouse xenograft models. Furthermore, liposomes formulated with this compound promote apoptosis and pro-death autophagy in MCF-7/DDP cells, alongside notable reductions in tumor volume and weight, showcasing its potential as a therapeutic agent in cancer treatment.

2-Acetylthiophene thiosemicarbazone is an antimicrobial agent that exhibits antimicrobial activity against a wide range of gram-negative (E. coli, P. aeruginosa, and S. marcescens ) and gram-positive (S. aureus, M. luteus, and B. cereus) bacteria. In addition, it has antimicrobial activity against a wide range of fungi (C. albicans, G. candidum, T. rubrum, F. oxysporum, A. flavus, and S. brevicaulis).

GUN69400 (also known as di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone hydrochloride) is an innovative thiosemicarbazone that inhibits the growth of neuroblastoma both in vivo and in vitro through multiple mechanisms.

N-Methylisatin beta-4',4'-diethylthiosemicarbazone is a bioactive chemical.

Thiacetazone (Diazam) is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis

ZMC2 is a potent iron chelator and antiproliferative agent demonstrating activity as a zinc metal carrier, with increased sensitivity observed in the p53-R175H cell lines.

NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.

CuATSP is a potent free radical trapping antioxidant (RTA) and ferroptosis inhibitor that reversibly adds a peroxyl radical to a bis (thiosemicarbazone) ligand to inhibit lipid peroxidation, showing therapeutic promise for diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease.

COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.

CAII-IN-3 (compound 3h) is a thiosemicarbazone derivative that potently inhibits carbonic anhydrase-II (CA-II), exhibiting an IC50 value of 13.4 μM [1].

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV) with an EC50 of 1.8 μM, directly binding to a hydrophobic pocket of the BVDV RdRp, and demonstrating antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).