tgase

BJJF078, an aminopiperidine derivative, is a potent inhibitor of recombinant human and mouse glutamine aminotransferase (TG2) activity, with IC50 values of 41 and 54 nM for human and mouse glutamine aminotransferase, respectively.BJJF078 inhibits TG1 enzyme, with an IC50 of 0.16 μM.BJJF078 can be used to study multiple sclerosis (MS). BJJF078 can be used to study multiple sclerosis (MS).

TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.

TG2-IN-3h is a transglutaminase (TGase) inhibitor used in the study of neurological and immune system disorders.

N-Phenylacrylamide inhibit human recombinant TGM2 by fluorescent transamidation assay.

GK921 is an inhibitor of transglutaminase 2 (TGase).

LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.

ZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease.

ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).

ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1 3 inhibitor with pIC50 of 4.4 7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

Glutathione ethyl ester acetate is the salt form of Glutathione ethyl ester. Glutathione ethyl ester is an antioxidant and cell-permeable Glutathione (GSH) donor that provides high efficiency of GSH to oocytes and is capable of restoring glutamate-induced oxidative stress and TGase up-regulation and prevent ethanol-induced oxidative stress and apoptosis in cells.

Antibacterial agent 197 (compound 1-deAA) functions as a termination inhibitor targeting non-classical anhydroglycosyl receptors and anhydrowall peptide-type peptidoglycan (PG) within bacterial TGase and exhibits efficacy against Staphylococcus aureus. It acts synergistically with Vancomycin, serving as its antibacterial adjuvant [1].