teratogenic

Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties.Macrozamin is a natural product isolated from Cycads.

The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

Cycloposine, a steroidal alkaloid present in the roots and rhizomes of Veratrum californicum, is known to possess teratogenic properties.

Azetidine-2-carboxylic acid, a non-proteinogenic amino acid homologue of proline found in common [beets], can be misincorporated into proteins in place of proline in various species, including humans, and is both toxic and teratogenic.

Aflatoxin G1 is a mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus, which is hepatotoxic, teratogenic, immunosuppressive, and carcinogenic, and is mainly found in contaminated cereals. Aflatoxin G1 inhibits RNA polymerase activity, affects RNA and protein synthesis, and causes damage to the liver and kidney.

Anagyrine, is the responsible teratogen from teratogenic lupins, can produce congenital deformities in calves typical of crooked calf disease; it also can induce red cell aplasia, vascular anomaly, and skeletal dysplasia.(-)-Anagyrine and (-)--Methylcytisine have nematicidal activities against Pine Wood Nematodes.

Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.