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Results for "

susceptible

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    86
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
Lamivudine
GR109714X, BCH-189
T0682134678-17-4
Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
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Mofarotene
Ro-40-8757, Ro 40-8757
T68104125533-88-2In house
Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and respiratory diseases.Mofarotene is a retinoic acid analog that binds to and activates retinoic acid receptors (RARs), which alters the expression of certain genes, leading to reduced cell differentiation and cell proliferation in susceptible cells.
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Phosphonic acid, [(2R,​3S)​-​3-​methyloxiranyl]​-​, calcium salt
phosphonomycin calcium, phosphomycin calcium, Fosfomycin calcium
T017026472-47-9
Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (phosphonomycin calcium) is an antibiotic, used for the treatment of urinary tract infections and intestinal infections caused by susceptible strains.
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Nitroxoline
8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline
T04004008-48-4
Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.
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Nalidixic acid
NSC-82174
T0909389-08-2
Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
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Nalidixic acid sodium salt
Baktogram, Sodium nalidixate
T0909L3374-05-8
Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.
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Penicillin V Potassium
Penicillin V potassium salt, Phenoxymethylpenicillin potassium salt
T1126132-98-9
Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally administered, broad-spectrum penicillin antibiotic used for treating mild to moderate infections caused by susceptible gram-positive organisms.
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Praziquantel
Pyquiton, Droncit, Biltricide
T143555268-74-1
Praziquantel (Droncit) increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. Praziquantel is a pyrazinoisoquinoline derivative with anthelminthic property. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm.
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Erythromycin estolate
Phtalic anhydride, ilosone
T152453521-62-8
Erythromycin estolate is a semi-synthetic derivative of erythromycin with good oral absorption and bioavailability tolerance. As a macrolide antibiotic, Erythromycin exerts its antibacterial action by inhibiting bacterial protein synthesis and is mainly used in studies for the treatment of respiratory, skin and soft tissue infections caused by susceptible bacteria. Erythromycin estolate may cause liver injury, including mild cholestatic hepatitis, jaundice, and paucity of bile ducts.
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7-10 days
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Sodium 4-phenylbutyrate
TriButyrate, Sodium Phenylbutyrate, Buphenyl
T15351716-12-7
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
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(-)-(S)-Equol
4',7-Isoflavandiol, (−)-Equol, Equol, 4',7-Dihydroxyisoflavan
T6491531-95-3
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.
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Tosufloxacin tosylate hydrate
Tosufloxacin p-Toluenesulfonate Hydrate, T-3262 Tosylate Hydrate, A-61827 tosylate hydrate
T80461400591-39-0
Tosufloxacin tosylate hydrate (A-61827 tosylate hydrate) is a fluoroquinolone antibacterial agent that is used to treat susceptible infections.
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Nafcillin sodium monohydrate
CL 8491
T13127177-50-6
Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.
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Targocil
T42081200443-21-5
Targocil is used as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) (MIC90s: 2 μg mL) for both MRSA and MSSA.
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Copanlisib
BAY 80-6946
T63221032568-63-0
Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. By inhibiting the PI3K signaling pathway, Copanlisib may impede tumor cell growth and survival in certain tumor populations. Dysregulated PI3K signaling, often linked to tumorigenesis, may also contribute to tumor resistance to various antineoplastic agents.
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Pyraclonil
T19533158353-15-2
Pyraclonil, a herbicide agent, effectively controls susceptible (S) and multiple-herbicide-resistant (MHR) E. indica populations as it acts as a proporphyrinogen oxidase (PPO) inhibitor.
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Pyrantel
Strongid, Pyrequan, Pyrantelum, Pirantele, Pin-X
T0395L15686-83-6
Pyrantel is a nicotinic receptor agonist and a depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes.
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2-4 weeks
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Dicloxacillin Sodium hydrate
Dicloxacillin sodium salt monohydrate, Dicloxacillin sodium monohydrate
T100113412-64-1
Dicloxacillin Sodium hydrate is a narrow-spectrum β-Lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria.
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Desmethyl ferroquine
SSR97213
T11006903546-18-9
Desmethyl ferroquine is the active and major metabolite of Ferroquine.Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains. Ferroquine is an antimalarial.
    7-10 days
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    Lincomycin
    U-10149, U10149
    T1235L154-21-2
    Lincomycin (U-10149) is a lincosamide antibiotic from Streptomyces that is effective against most susceptible gram-positive and cell wall-less bacteria and is generally used in patients for whom penicillin is not available.
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    7-10 days
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    Imipenem
    N-Formimidoyl thienamycin, MK0787
    T12449264221-86-9
    Imipenem (MK0787) is a thienomycin derivative that belongs to the class of antibiotics with antibacterial activity and partial inhibition against gram-positive and gram-negative bacteria. Imipenem can be used to study carbapenem non-susceptible infections and Pseudomonas aeruginosa biofilm infections.
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    Sulbactam
    CP45899
    T163168373-14-8
    Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam antibiotics by the enzyme. Combining this agent with a beta-lactamase susceptible antibiotic, such as penicillins or a cephalosporin, to treat infections caused by beta-lactamase producing organisms, results in a decreased turnover rate of the beta-lactamase sensitive antibiotic and enhances its antibacterial activity.
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    HDAC-IN-76
    T200090
    HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.
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    Nafithromycin
    WCK 4873
    T2001021691240-78-4
    Nafithromycin (WCK 4873) serves as an orally administered antibiotic effective against community-acquired pneumonia organisms such as Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Methicillin-susceptible Staphylococcus aureus. It displays a minimum inhibitory concentration (MIC 90) of 0.12 mg liter against both macrolide-resistant and telithromycin-insensitive Streptococcus pneumoniae.
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