sup-t1

TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.

AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC

AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.

3-Hydroxypyridine exhibits inhibitory activity against DNA topoisomerase 2-beta (Topo IIβ) and HIV-1 replication in Sup-T1 cells, making it useful for studying the HIV-1 virus.

gp120-IN-2 (compound 4i) is a potent inhibitor of HIV-1 gp120, demonstrating anti-HIV-1 activity with an IC50 of 7.5 μM and a CC50 of 112.93 μM. It shows dose-dependent cytotoxicity in SUP-T1 cells [1].

gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with a CC50 of 100.90 μM and IC50 of 2.2 μM, inhibiting gp120-mediated virus entry into cells and exhibiting anti-HIV-1 activity with dose-dependent cytotoxicity in SUP-T1 cells [1].