srpk1

Srpk1-IN-1 (compound 12) serves as a potent inhibitor of SRPK 1, demonstrating an IC 50 value of 0.3 nM [1].

CLK1 2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1 2-IN-3 induces nuclear speckle enlargement, which induces S6K pre-mRNA-selective splicing and subsequent inhibition of cell growth of multiple cancer cell types. cancer cell types cell growth.

SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1 2 (IC50s: 35.6 and 98 nM, respectively).

SRPIN340 (SRPK inhibitor), a serine arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).

CLK1 2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.

SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.

SPHINX31 is a potent inhibitor of serine arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).

MSC-1186 is a potent and highly selective inhibitor targeting the pan-SRPK family, including SRPK1, SRPK2, and SRPK3, with IC 50 values of 2.7 nM, 81 nM, and 0.6 nM, respectively. Its specificity and effectiveness make it suitable for cancer research applications.

Antiangiogenic Agent 5 (Compound 17) exhibits potent anti-angiogenic activity by inhibiting SRPK 1 with an IC50 of 1.3 nM [1].