sm1 71

SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines.

N-Desethyl-N-Methyl Vardenafil (Standard) is the standard substance of N-Desethyl-N-Methyl Vardenafil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. N-Desethyl-N-methyl Vardenafil, a potential impurity in commercial vardenafil preparations, functions as a phosphodiesterase 5 (PDE5) inhibitor, similar to its parent compound. With an IC50 value of 2 nM, it exhibits potent inhibitory activity against PDE5.

N-Dodecyl-N,N-dimethyldodecan-1-aminium bromide (Standard) is the standard substance of N-Dodecyl-N,N-dimethyldodecan-1-aminium bromide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. N-Dodecyl-N,N-dimethyldodecan-1-aminium bromide is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Nebivolol hydrochloride (Standard) is the standard substance of Nebivolol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

Neobavaisoflavone (Standard) is the standard substance of Neobavaisoflavone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can significantly inhibit the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p4, IL-12p7, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.

Poncirin (Standard) is a reference standard for research and analysis in studies involving Poncirin. 1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enhances osteoblast differentiation in mesenchymal stem cellsincreased bone mineral density, and improves trabecular microarchitecture likely reflect increases bone formation and decreases bone resorption in GIO mice.

Neomycin sulfate (Standard) is the certified analytical reference standard of Neomycin sulfate developed for quantitative analysis, quality control, and biochemical research applications, and as a broad-spectrum aminoglycoside antibiotic, Neomycin sulfate (Framycin sulfate) inhibits bacterial protein synthesis by binding ribosomal subunits, while being widely applied as a selective agent for screening prokaryotic and eukaryotic cells harboring Neo resistance genes.

Neotame (Standard) is the standard substance of Neotame, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Neotame (HSDB 7965) is a white-colored, dipeptide methyl ester, which is found to be a highly potent and non-nutritive sweetener or flavour enhancer and hence finds applications in a variety of foods.

Nequinate (Standard) is the standard substance of Nequinate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nequinate is an anticoccidial agent, preventing coccidiosis .

Nerolidol (Standard) is the standard substance of Nerolidol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presence of oxidative lesions.

Nervonic Acid Methyl Ester (Standard) is the standard substance of Nervonic Acid Methyl Ester, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nervonic Acid Methyl Ester is a natural product.