sarm1

SARM1-IN-2 is a potent SARM1 inhibitor for the study of metabolic and neurological related diseases.

Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

SARM1-IN-3 (Example 30) is an inhibitor of SARM1. This compound is employed in the study of chemotherapy-induced peripheral neuropathy (CIPN).

Sulfo-ara-F-NMN is an analogue of nicotinamide mononucleotide (NMN) with cellular permeability. Sulfo-ara-F-NMN was selective to activate SARM1 and inhibited CD38 with an IC50 of about 10 μM. Activation by Sulfo-ara-F-NMN to Z-48 or NMN, which has a higher cyclase activity, causes conformational changes in SARM1, resulting in cADPR production, NAD depletion, and non-apoptotic cell death.

5-Chloroisoquinoline (compound 42) acts as an inhibitor of SARM1 (Sterile alpha and toll interleukin receptor (TIR) motif containing protein 1), an enzyme involved in axonal degeneration through a ternary complex mechanism mediating various activities. This compound is utilized in research related to neurodegenerative diseases or axonal degeneration.