r-41400

Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.

(-)-Ketoconazole is a potential mitochondrial CYP24A1 inhibitor and has antifungal activity against Aspergillus fumigatus.

(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.

(Rac)-Ketoconazole ((Rac)-R 41400) is an orally active antifungal imidazole compound. It inhibits ergosterol synthesis in fungi by targeting the cytochrome P450-dependent enzyme, 14α-sterol demethylase (CYP51), on the fungal cell membrane. This disruption leads to dysfunction of the cell membrane, ultimately hindering fungal growth and proliferation. (Rac)-Ketoconazole is applicable in studying fungal infections.