Search Result

Search Results for " plasmin "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T78018	Plasminogen
	Plasminogen is a zymogen secreted as a precursor protein that, when cleaved by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA), is converted into plasmin. Plasmin is a protease with broad spec...
T13408	ZK824190		Others , Serine Protease
	ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).		Others , Serine Protease
T8362	Benzamidine hydrochloride	Benzamidine HCl	Serine/threonin kinase , Serine Protease
	Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).		Serine/threonin kinase , Serine Protease
T6370	AEBSF hydrochloride	AEBSF HCl,Pefabloc SC	Thrombin , Serine Protease , Influenza Virus
	AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.		Thrombin , Serine Protease , Influenza Virus
T3359	Aprotinin	Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others , Serine Protease , Influenza Virus , Proteasome
	Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...		Others , Serine Protease , Influenza Virus , Proteasome
TP1792L	KKI-5 acetate(97145-43-2 free base)		Serine Protease
	KKI-5 acetate is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema.		Serine Protease
T28248	Ono-3307 mesylate	Ono3307,Ono 3307,Ono-3307
	Ono-3307 is a protease inhibitor potentially for the treatment of thrombosis. ONO-3307 competitively inhibited trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein and chymotrypsin; and their Ki values we...
T0372	Gabexate mesylate	FOY	Factor Xa , Serine Protease , Proteasome
	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh...		Factor Xa , Serine Protease , Proteasome
T9670L	Patamostat HCl	Patamostat HCl（114568-26-2 Free base）	Serine Protease , Protease
	Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamosta...		Serine Protease , Protease
T13409	ZK824859		Others
	ZK824859 is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).		Others
T13409L	ZK824859 hydrochloride (2271122-53-1 free base)	ZK824859 hydrochloride	Others
	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).		Others
T25810	Micropeptin 478A	Micropeptin 478 A,Micropeptin 478-A
	Micropeptin 478A is a plasmin inhibitor from the Cyanobacterium Microcystis aeruginosa.
T25811	Micropeptin 478B
	Micropeptin 478B is a plasmin inhibitor from the Cyanobacterium Microcystis aeruginosa.
T38521	Patamostat mesylate	E-3123 mesylate
	Patamostat mesylate (E-3123) is a highly potent protease inhibitor, displaying strong inhibitory activity against trypsin, plasmin, and thrombin, with IC 50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compoun...
T36225	N-p-Tosyl-Gly-Pro-Lys-pNA (acetate)
	N-p-Tosyl-Gly-Pro-Lys-pNA is a colorimetric substrate for plasmin.1,2,3Plasmin binds and hydrolyzes N-p-tosyl-Gly-Pro-Lys-pNA to releasep-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as...
T22451	UK-371804 HCl		Serine Protease
	UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fold versus plasmin and 4000-fold versus tPA).		Serine Protease
T69500	YO-2
	YO-2 is a selective plasmin inhibitor. YO-2 induces thymocyte apoptosis via activation of caspase cascade.
T38736	Nattokinase
	Nattokinase is a powerful fibrinolytic enzyme that effectively hydrolyzes fibrin and plasmin substrate, leading to the breakdown of blood clots. Its efficacy renders it valuable for cardiovascular disease studies.
T40614	LCKLSL
	LCKLSL, an N-terminal hexapeptide, acts as a competitive inhibitor of annexin A2 (AnxA2), effectively preventing the binding of tissue plasminogen activator (tPA) to AnxA2 while also inhibiting the generation of plasmin....
T72113	6-Aminocaproic acid hydrochloride	EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
	6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid derivative, serves as a potent, orally active antifibrinolytic agent by inhibiting plasmin and plasminogen. It functions through competitive binding to lysin...
TP1013	N-CBZ-Phe-Arg-AMC	Z-FR-AMC
	N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a substrate for serine proteases, including cathepsins, kallikrein and plasmin. Absorption/emission of substrate = 330/390 nm (weak fluorescence); absorption/emission of end product (AMC) ...
TP1792	KKI-5
	KKI 5 is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema.
T37019	P-APMSF (hydrochloride)
	p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these pr...
T6564L	Leupeptin	Leupeptin Ac-LL,NK-381
	Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), ...
T41085	UK122	UK122
	UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA),...
T62731	ZK824190 hydrochloride
	ZK824190 hydrochloride is a selective, orally active urokinase-type fibrinogen activator (uPA) inhibitor that acts on uPA (IC50: 237 nM), tPA (IC50: 1600 nM) and Plasmin (IC50: 1850 nM). hydrochloride can be used in stud...
T72736	Aeruginosin 98-B
	Aeruginosin 98-B, a protease inhibitor, effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 0.6, 7.0, and 10.0 μg/mL, respectively.
TP2482	LCKLSL acetate	LCKLSL acetate(533902-29-3 free base)	Annexin A
	LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic ...		Annexin A
T36962	MMP Inhibitor I (trifluoroacetate salt)
	MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urea...
T69294	UK‑396082
	UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research...
T69297	Leupeptin HCl
	Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin...
T78015	LCKLSL hydrochloride
	LCKLSL hydrochloride, an N-terminal hexapeptide and competitive annexin A2 (AnxA2) inhibitor, effectively disrupts the interaction between tissue plasminogen activator (tPA) and AnxA2. It additionally hinders plasmin gen...
T9670	Patamostat
	Patamostat (E-3123) is a potent protease inhibitor that effectively inhibits trypsin, plasmin, and thrombin, exhibiting IC50 values of 39 nM, 950 nM, and 1.9 µM, respectively. Research suggests that Patamostat might supp...
T35579	PKSI-527
	PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respect...
T73701	Urokinase (peptidolytic)
	Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in t...
T27698	JTV-803 mesylate	JTV803,JTV 803,JTV-803
	JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting ...

Compounds

Target: Others, Serine Protease

Benzamidine hydrochloride

T8362

Synonym: Benzamidine HCl

Target: Serine/threonin kinase, Serine Protease

AEBSF hydrochloride

T6370

Synonym: AEBSF HCl,Pefabloc SC

Target: Thrombin, Serine Protease, Influenza Virus

Aprotinin

T3359

Synonym: Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin

Target: Others, Serine Protease, Influenza Virus, Proteasome

KKI-5 acetate(97145-43-2 free base)

TP1792L

Synonym:

Target: Serine Protease

Ono-3307 mesylate

T28248

Synonym: Ono3307,Ono 3307,Ono-3307

Target: Factor Xa, Serine Protease, Proteasome

Patamostat HCl

T9670L

Synonym: Patamostat HCl（114568-26-2 Free base）

Target: Serine Protease, Protease

ZK824859 hydrochloride (2271122-53-1 free base)

T13409L

Synonym: ZK824859 hydrochloride

Target: Others

Micropeptin 478A

T25810

Synonym: Micropeptin 478 A,Micropeptin 478-A

Synonym: E-3123 mesylate

Target:

N-p-Tosyl-Gly-Pro-Lys-pNA (acetate)

Target: Serine Protease

6-Aminocaproic acid hydrochloride

T72113

Synonym: EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride

p-APMSF (hydrochloride)

Synonym: Leupeptin Ac-LL,NK-381

ZK824190 hydrochloride

Synonym: LCKLSL acetate(533902-29-3 free base)

Target: Annexin A

MMP Inhibitor I (trifluoroacetate salt)

Urokinase (peptidolytic)

Synonym: JTV803,JTV 803,JTV-803

Target:

Cat No.	Product Name	Synonyms	Targets
T0881	6-Aminocaproic acid	EACA,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid	Others
	6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.		Others

Natural Products

6-Aminocaproic acid

T0881

Synonym: EACA,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00302	Serpin F2 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Alpha-2-antiplasmin, also called Serpin F2, is a serine protease inhibitor (serpin) responsible for inactivating plasmin, and an important enzyme participates in fibrinolysis and degradation of other proteins. In liver c...
TMPY-04860	Alpha 2 Antiplasmin/SerpinF2 Protein, Rat, Recombinant (His)	Rat	HEK293
	SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPY-01398	Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His)	Human	HEK293
	SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPY-01026	Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPH-01870	Plasminogen Protein, Human, Recombinant (His)	Human	E. coli
	Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the...
TMPH-01080	Ceruloplasmin Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the ...
TMPJ-00254	TGF beta 3 Protein, Human/Mouse/Rat, Recombinant	Human,Mouse,Rat	Human Cells
	Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes acti...
TMPY-00904	Urokinase/uPA Protein, Human, Recombinant (His)	Human	HEK293
	Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...
TMPJ-00452	Serpin A1a Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elast...
TMPK-01043	VEGFC Protein, Human, Recombinant (His & Avi)	Human	HEK293
	the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet...
TMPK-01044	VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet...
TMPY-02859	TFPI2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotei...
TMPJ-01282	Serpin B12 Protein, Human, Recombinant (His)	Human	Human Cells
	Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular f...
TMPJ-01069	Serpin A1e Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-...
TMPY-01004	TFPI2 Protein, Human, Recombinant (His)	Human	HEK293
	Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotei...
TMPY-02329	TFPI2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotei...
TMPJ-00501	CLEC3B Protein, Human, Recombinant (His)	Human	Human Cells
	C-Type Lectin Domain Family 3 Member B (CLEC3B) is a serum and tissue protein and it contais a C-type lectin which binds to Ca++. CLEC3B is originally found in plasma, the concentrations approximately 10mg/l. It can bind...
TMPJ-00234	AMBP Protein, Human, Recombinant (His)	Human	Human Cells
	Protein AMBP belongs to the calycin superfamily and Lipocalin family. AMBP can be cleaved into three chains: α-1-microglobulin, inter-α-trypsin inhibitor light chain and trypstatin. AMBP is expressed by the liver and sec...
TMPY-01718	Serpin B12 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPY-00938	TPA Protein, Human, Recombinant	Human	HEK293
	Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPJ-00505	Serpin A1 Protein, Human, Recombinant (aa 25-418, His)	Human	Human Cells
	Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent,...
TMPY-00937	TPA Protein, Human, Recombinant (hFc)	Human	HEK293
	Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPY-02898	TPA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPJ-00649	CPB2 Protein, Human, Recombinant (His)	Human	Human Cells
	Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the pl...
TMPJ-01083	Serpin E2 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice lea...
TMPJ-00734	KNG1 Protein, Human, Recombinant (His)	Human	Human Cells
	Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ...
TMPY-02628	Neuroserpin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ...
TMPH-00324	SVTLE Protein, Calloselasma rhodostoma, Recombinant (His)	Calloselasma rhodostoma	Yeast
	Thrombin-like snake venom serine protease that acts as an anticoagulant. It cleaves fibrinogen (FGA) to split off the A-fibrinopeptides (A, AY and AP), but not the B-fibrinopeptide. The resulting fibrin polymers are impe...
TMPY-01241	Neuroserpin Protein, Human, Recombinant (His)	Human	HEK293
	Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ...
TMPJ-00332	TPA Protein, Human, Recombinant (His)	Human	Human Cells
	Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs...
TMPY-04504	Urokinase/uPA Protein, Rat, Recombinant (His)	Rat	HEK293
	Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...