pip4kγ

NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease.

PIP4K-IN-a131 is a selective inhibitor of phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (PIP4K2A), with inhibitory activity in the micromolar range against PIP4K2A and the broader PIP4K family (IC₅₀ ≈ 1.9 μM and 0.6 μM, respectively). PIP4K-IN-a131 suppresses PIP4K-mediated lipid signaling and cell cycle–related processes, and exhibits antiproliferative effects in cancer cells.

UNC3230 is a potent, selective, and ATP-competitive PIP5K1C inhibitor with an IC50 of approximately 41 nM. UNC3230 (UNC 3230) also inhibits PIP4K2C.

BAY-091 is a novel, potent, and highly selective inhibitor of PIP4K2A kinase.