pft β

Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).

FTI 276 TFA is effective against plasmodium falciparum and humans.It is a protein-based nikyltransferase (PFT) inhibitor with an IC50s of 0.9 nM and 0.5 nM, respectively.

Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.

Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.

Perfluorotetradecanoic acid (PFTeDA) is a PPARγ antagonist. It binds to the ligand-binding domain of human PPARγ, with an IC50 of 22.8 μM and a Kd of 157.8 μM. Perfluorotetradecanoic acid inhibits Leydig cell function by inducing oxidative stress and apoptosis (Apoptosis). Although it stimulates corticosterone biosynthesis, it inhibits aldosterone production.

PfThrRS-IN-1 (compound 11) is a potent inhibitor of the Plasmodium falciparum threonyl-tRNA synthetase (PfThrRS), exhibiting an IC50 value of 0.1 μM. This compound is also an effective antimalarial (antimalaria) agent.

FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.FPFT-2216 has potential antitumor activity and can be used to study diseases of the immune system.FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.

Ir[p-F(t-Bu)-ppy]3 is a useful organic compound for research related to life sciences and the catalog number is T64556.

Perfluoro-n-tetradecanoic acid-13C2 (PFTeDA-13C2) is the 13C labeled version of Perfluoro-n-tetradecanoic acid.